Anti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice

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Ahmadi Afshar Somayyeh; Jafari khataylou Yaser

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:29 | Issue:181 Page(s): 12-25

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Title

Anti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice

Author(s)

Ahmadi Afshar Somayyeh | Jafari khataylou Yaser | Issue Writer Certificate

Keywords

Euphorbia myrsinitisQ1

pro-inflammatory/anti-inflammatory cytokinesQ1

LPSQ2

miceQ2

nitric oxideQ2

Abstract

Background and purpose: Many herbs including Euphorbia have immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of the ethanolic extract of E. myrsinites. Materials and methods: In this experimental study, 40 Swiss albino male mice were randomly divided into 4 groups. Group A included healthy mice, group B was induced by lipopolysaccharide (LPS), group C received the ethanolic extract of E. myrsinites 7 days before LPS induction. Group D received the plant extract at the same time with LPS induction. Then, blood samples were collected (2 and 6 h after LPS induction) and IL-4, IL-10, TNF-α , and IFN-γ and nitric oxide production were evaluated. Results: Two hours after LPS induction, the levels of IL-4 and IL-10 in groups C and D increased significantly and IFN-γ level decreased significantly compared to those in group B (P=0. 0425). But, six hours after LPS induction, TNF-α level significantly increased in group B compared to that in groups C and D (P=0. 0473), but IL-4 and IL-10 levels increased significantly in groups C and D compared to those in group B (P=0. 0411). The levels of nitric oxide, 2 and 6 hours after LPS induction, significantly decreased in groups C and D compared to those in group B (P=0. 0421). Conclusion: E. myrsinites ethanolic extract has immunomodulatory effects and could be used as an effective drug in inflammatory diseases such as septic shock through reduced production of proinflammatory cytokines.

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APA: Copy

Ahmadi Afshar, Somayyeh, & Jafari khataylou, Yaser. (2020). Anti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(181 ), 12-25. SID. https://sid.ir/paper/362887/en

Vancouver: Copy

Ahmadi Afshar Somayyeh, Jafari khataylou Yaser. Anti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(181 ):12-25. Available from: https://sid.ir/paper/362887/en

IEEE: Copy

Somayyeh Ahmadi Afshar, and Yaser Jafari khataylou, “Anti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 181 , pp. 12–25, 2020, [Online]. Available: https://sid.ir/paper/362887/en

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