Evaluation of Antioxidant, Alpha-Glucosidase Enzyme Inhibitory and Antimicrobial Activities of Anthraquinone and Aloe-emodin

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GHAZNAVI M.; MOSLEHISHAD M.; GHAMARI F.

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Paper Information

Journal: Iranian Journal of Nutrition Sciences and Food Technology Year:2019 | Volume:14 | Issue:2 Page(s): 117-124

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Title

Evaluation of Antioxidant, Alpha-Glucosidase Enzyme Inhibitory and Antimicrobial Activities of Anthraquinone and Aloe-emodin

Author(s)

GHAZNAVI M. | MOSLEHISHAD M. | GHAMARI F. | Issue Writer Certificate

Keywords

Aloe veraQ1

Aloe-emodinQ1

AnthraquinoneQ1

Antioxidant propertiesQ1

Alpha-glucosidase inhibitoryQ1

Antimicrobial activityQ2

Abstract

Background and Objectives: Aloe-vera is one of the most valuable medicinal plants in the world. The aim of this study was to evaluate the antioxidant, Alpha-glucosidase inhibitory and antimicrobial properties of aloe-vera derivatives including Aloe-emodin and Anthraquinone. Materials & Methods: Antioxidant activity of Aloe-emodin and Anthraquinone was determined using ABTS method. Antimicrobial activity of Aloe-emodine and Anthraquinone was evaluated against Bacillus cereus, Klebsiella pneumoniae, Candida albicans, and Pseudomonas aeruginosa. To determine the inhibition of alpha-glucosidase enzyme, pNPG)p-nitrophenyl-α-D-glucopyranoside)bwas used as substrate. Enzymatic activity was determined by measuring the absorption of para-nitrophenol produced in the solution. Results: The results showed that Aloe-emodin and Anthraquinone do not have an antioxidant effect at 0. 05mg/mL concentration. The results of the alpha-glucosidase enzyme inhibitory test for Aloe-emodin and Anthraquinone Aloe vera also showed a positive and significant correlation between the sample’ s concentration and its Alpha-glucosidase inhibitory activity (p˂ 0. 05). At concentrations of 0. 18 and 0. 05mg/mL Aloe-emodin and Anthraquinone had a 50% inhibitory effect on the alpha-glucosidase enzyme. Therefore, the inhibitory effect of Anthraquinone was higher than that of Aloe-emodin. In microbial test, the diameter of the non-growth zone indicated that Aloe-emodin had the highest effect on Bacillus cereus and the least effect on Pseudomonas aeruginosa (p˂ 0. 05). Alsot Anthraquinone had the highest effect on Candida albicans and Klebsiella pneumoniae and the least effect on Pseudomonas aeruginosa (p˂ 0. 05). According to the results of alpha-glucosidase inhibitor test, Anthraquinone is a potent inhibitor, and the Antimicrobial activity of Anthraquinone is higher than that of Aloe-emodin. Conclusion: Considering the favorable antimicrobial and inhibitory properties of alpha-glucosidase, it is recommended to use it as a natural additive in food industry.

Cites

The Effect of Aloe Vera Extract on Immunologic Stress in Active Girls Following an Exhaustive CrossFit Exercise

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APA: Copy

GHAZNAVI, M., MOSLEHISHAD, M., & GHAMARI, F.. (2019). Evaluation of Antioxidant, Alpha-Glucosidase Enzyme Inhibitory and Antimicrobial Activities of Anthraquinone and Aloe-emodin. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 14(2 ), 117-124. SID. https://sid.ir/paper/363367/en

Vancouver: Copy

GHAZNAVI M., MOSLEHISHAD M., GHAMARI F.. Evaluation of Antioxidant, Alpha-Glucosidase Enzyme Inhibitory and Antimicrobial Activities of Anthraquinone and Aloe-emodin. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2019;14(2 ):117-124. Available from: https://sid.ir/paper/363367/en

IEEE: Copy

M. GHAZNAVI, M. MOSLEHISHAD, and F. GHAMARI, “Evaluation of Antioxidant, Alpha-Glucosidase Enzyme Inhibitory and Antimicrobial Activities of Anthraquinone and Aloe-emodin,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 14, no. 2 , pp. 117–124, 2019, [Online]. Available: https://sid.ir/paper/363367/en

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