Comparison of the effect of 8 weeks of continuous and high intensity interval training on the gene expression of TIMP-2 and MMP-2 in male diabetic rats

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AKBARI NEDA; PEERI MAGHSOUD; AZARBAYJANI MOHAMMAD ALI; DELFAN MARYAM

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Journal: Razi Journal of Medical Sciences Year:2020 | Volume:26 | Issue:10 Page(s): 107-116

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Title

Comparison of the effect of 8 weeks of continuous and high intensity interval training on the gene expression of TIMP-2 and MMP-2 in male diabetic rats

Author(s)

AKBARI NEDA | PEERI MAGHSOUD | AZARBAYJANI MOHAMMAD ALI | DELFAN MARYAM | Issue Writer Certificate

Keywords

Continuous trainingQ1

High intensity Interval training (HIIT)Q1

MMP-2Q1

TIMP-2Q1

Insulin resistanceQ1

Abstract

Background: Regular aerobic exercise training is one of the most effective methods for the prevention of cardiovascular disease in the patiens with type 2 diabetes. The purpose of this study was to compare the effects of continuous and High intensity Interval training (HIIT) on the gene expression of TIMP-2 and MMP-2 genes in diabetic rats. Methods: This is an experimental study. For this purpose, 21 male diabetic rats were divided into 3 groups of 7; Continuous Aerobic Exercise (CT), High intensity Interval training (HIIT) and Control (C). Diabetes was induced in a pellet with a high-fat diet (30% fat and 25% fructose) for 16 weeks. After the last exercise and recovery session, the subjects were sacrificed and their left ventricle was extracted. Glucose oxidase was used to measure glucose in plasma using ELISA method to measure insulin levels and HOMA-IR method was used to measure Insulin resistance index. PCR-Real time was used to determine the expression of TIMP-2 and MMP-2 genes and comparison of the groups by one-way ANOVA and LSD post hoc test to determine the difference between groups at alpha level of 5%. Results: The results showed that gene expression of MMP-2 in both groups of CT (p=0. 01) and HIIT (p=0. 001) showed a significant decrease compared to the control group. The TIMP-2 gene expression in both CT (p=0. 03) and HIIT (p=0. 001) groups was significantly higher than the control group. Weight in the groups did not show any significant changes compared to the control group. Glucose and insulin in the training groups showed a significant difference compared to the control group, and the HIIT did not show a significant difference between the two groups in terms of continuation training group. Conclusion: It can be concluded 8 weeks of HIIT training with a greater effect on reducing the expression of MMP-2 gene and modifying the expression of TIMP-2 gene in myocardium in a poorly regulated diabetic rats and possibly reducing the risk of diabetic cardiomyopathy.

Cites

Effect of Eight Weeks of Aerobic Interval Training and Urtica dioica Supplement on Some Inflammatory Indicators and Glycemic Control in Men with Type 2 Diabetes

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APA: Copy

AKBARI, NEDA, PEERI, MAGHSOUD, AZARBAYJANI, MOHAMMAD ALI, & DELFAN, MARYAM. (2020). Comparison of the effect of 8 weeks of continuous and high intensity interval training on the gene expression of TIMP-2 and MMP-2 in male diabetic rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(10 ), 107-116. SID. https://sid.ir/paper/363390/en

Vancouver: Copy

AKBARI NEDA, PEERI MAGHSOUD, AZARBAYJANI MOHAMMAD ALI, DELFAN MARYAM. Comparison of the effect of 8 weeks of continuous and high intensity interval training on the gene expression of TIMP-2 and MMP-2 in male diabetic rats. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2020;26(10 ):107-116. Available from: https://sid.ir/paper/363390/en

IEEE: Copy

NEDA AKBARI, MAGHSOUD PEERI, MOHAMMAD ALI AZARBAYJANI, and MARYAM DELFAN, “Comparison of the effect of 8 weeks of continuous and high intensity interval training on the gene expression of TIMP-2 and MMP-2 in male diabetic rats,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 10 , pp. 107–116, 2020, [Online]. Available: https://sid.ir/paper/363390/en

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