مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

375
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Study of rs2858060 polymorphism in Lnc-Ang362 long non-coding sequence as an informative marker in screening of atherosclerotic coronary artery diseases: pilot study

Pages

  38-43

Abstract

 Background: atherosclerotic coronary artery disease (CAD) is the major cause of death and disability by affecting more than 20% of the individuals over age 35. Lnc-Ang362, an AngII-upregulated long non-coding RNA transcript, regulates the vascular smooth muscle cell proliferation by targeting miR-221 and miR-222. The present study aimed to evaluate the association of the rs2858060 polymorphism in Lnc-Ang362 transcript with the risk of the atherosclerotic CAD. Methods: This case-control study included 150 affected individuals with CAD and 149 healthy controls. T-ARMS PCR method was used to determine the genotypes of each sample for the polymorphic marker rs2858060 in Lnc-Ang362 gene. Results: The frequency of the homozygote genotype CC in control group (42. 3%) was higher than patient group (31. 3%). Individuals with CC genotype were shown to have lower risk of CAD (OR: 0. 61; 95%CI: 0. 36-1. 01; p= 0. 05). The frequency of the polymorphic allele C was 0. 51% in control group and 0. 43% in patients (OR: 0. 68; 95%CI: 0. 49-0. 94; p= 0. 02). Conclusion: The long non-coding RNA transcript Lnc-Ang362 may involve in the pathogenesis of the CAD and could consider as a molecular target for prognosis and screening of the patients with CAD.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    BAZOOEI, KHADIJEH, NASIRI, MAHBOOBEH, & Kamfiroozie, Hajar. (2019). Study of rs2858060 polymorphism in Lnc-Ang362 long non-coding sequence as an informative marker in screening of atherosclerotic coronary artery diseases: pilot study. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 41(3 ), 38-43. SID. https://sid.ir/paper/363673/en

    Vancouver: Copy

    BAZOOEI KHADIJEH, NASIRI MAHBOOBEH, Kamfiroozie Hajar. Study of rs2858060 polymorphism in Lnc-Ang362 long non-coding sequence as an informative marker in screening of atherosclerotic coronary artery diseases: pilot study. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;41(3 ):38-43. Available from: https://sid.ir/paper/363673/en

    IEEE: Copy

    KHADIJEH BAZOOEI, MAHBOOBEH NASIRI, and Hajar Kamfiroozie, “Study of rs2858060 polymorphism in Lnc-Ang362 long non-coding sequence as an informative marker in screening of atherosclerotic coronary artery diseases: pilot study,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 41, no. 3 , pp. 38–43, 2019, [Online]. Available: https://sid.ir/paper/363673/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top