ASSOCIATION OF THE RS7887062 POLYMORPHISM IN LNC-ANG362 WITH ATHEROSCLEROTIC CORONARY ARTERY DISEASE IN LOW RISK PATIENTS

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BAZOOEI KHADIJEH; NASIRI MAHBOOBEH; KAMFIROUZI HAJAR

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:161 Page(s): 24-32

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Title

ASSOCIATION OF THE RS7887062 POLYMORPHISM IN LNC-ANG362 WITH ATHEROSCLEROTIC CORONARY ARTERY DISEASE IN LOW RISK PATIENTS

Author(s)

BAZOOEI KHADIJEH | NASIRI MAHBOOBEH | KAMFIROUZI HAJAR | Issue Writer Certificate

Keywords

LNC-ANG362Q1

CORONARY ARTERY DISEASEQ3

POLYMORPHISMQ2

Abstract

Background and purpose: A long non-coding transcript LNC-ANG362 plays critical role on theexpression of miR-221 and miR-222. Knockdown of LNC-ANG362 reduces the expression of thesemiRNAs as well as vessel smooth muscle cell proliferation in response to vascular injury. This study, forthe first time, considered the possible association between LNC-ANG362 rs7887062A/G POLYMORPHISMwith the risk of atherosclerotic CORONARY ARTERY DISEASE (CAD) in low risk patients. Materials and methods: In this case-control study, 299 subjects, including 150 patients withatherosclerotic CAD and 149 healthy individuals (control group) enrolled. Genotyping of the rs7887062was done using PCR-RFLP method. Data were analyzed using SPSS v. 19. Results: The frequency of heterozygote AG and G-allele carriage (GG+AG) genotypes weregreater in controls compared to the patients, supporting the protective role against CAD. The G allelereduced the risk of disease (OR: 0. 32, 95%CI: 0. 15-0. 7, P=0. 004). In cross tabulation of the studypopulation based on gender, reduced risk of CAD in the presence of AG and G-carriage genotypes wasseen in both males and females. Conclusion: LNC-ANG362 variant could be considered as a molecular screening marker for lowrisk susceptible subjects to atherosclerotic CAD.

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APA: Copy

BAZOOEI, KHADIJEH, NASIRI, MAHBOOBEH, & KAMFIROUZI, HAJAR. (2018). ASSOCIATION OF THE RS7887062 POLYMORPHISM IN LNC-ANG362 WITH ATHEROSCLEROTIC CORONARY ARTERY DISEASE IN LOW RISK PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(161 ), 24-32. SID. https://sid.ir/paper/45466/en

Vancouver: Copy

BAZOOEI KHADIJEH, NASIRI MAHBOOBEH, KAMFIROUZI HAJAR. ASSOCIATION OF THE RS7887062 POLYMORPHISM IN LNC-ANG362 WITH ATHEROSCLEROTIC CORONARY ARTERY DISEASE IN LOW RISK PATIENTS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(161 ):24-32. Available from: https://sid.ir/paper/45466/en

IEEE: Copy

KHADIJEH BAZOOEI, MAHBOOBEH NASIRI, and HAJAR KAMFIROUZI, “ASSOCIATION OF THE RS7887062 POLYMORPHISM IN LNC-ANG362 WITH ATHEROSCLEROTIC CORONARY ARTERY DISEASE IN LOW RISK PATIENTS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 161 , pp. 24–32, 2018, [Online]. Available: https://sid.ir/paper/45466/en

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