The Effect of Aerobic Training and Adenosine on the Expression of SREBP-1C and A1 Receptor in Hepatic Fat-fed Rats

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Hedayati katooli A.; AZARBAYJANI M.A.; BANAEIFAR A.; ARSHADI S.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2019 | Volume:14 | Issue:1 Page(s): 1-9

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Title

The Effect of Aerobic Training and Adenosine on the Expression of SREBP-1C and A1 Receptor in Hepatic Fat-fed Rats

Author(s)

Hedayati katooli A. | AZARBAYJANI M.A. | BANAEIFAR A. | ARSHADI S. | Issue Writer Certificate

Keywords

Aerobic exerciseQ1

High-intensity interval training (HIIT)Q1

SREBP1-cQ1

Adenosine-A1 receptorQ1

High fat dietQ1

Abstract

Background and Objectives: Few studies have examined so far the effect of adenosine receptors’ injection and its downstream pathway on the liver’ s fat metabolism. The aim of this study was to investigate the type of Aerobic exercise and adenosine on the expression of sterol regulatory binding protein 1c SREBP-1c and the adenosine receptor A1 in the liver in the rats fed with high-fat foods. Materials and Methods: Forty rats were randomly divided into eight groups: control of standard diet, High fat diet, High fat diet and placebo, High fat diet and Adenosine injection, High fat diet+high-intensity interval training (HIIT) and adenosine injection, High fat diet+HIIT and placebo, High fat diet+aerobic training and adenosine injection, High fat diet+aerobic training, and placebo. The subjects received 13 weeks of high-fat diet in the first stage. In the second stage, they trained for 12 weeks each week for 5 sessions. An analysis of one-way independent variance was used to analyze the data in the diet groups, and two-way analysis of variance was used to determine the effect of exercise interaction and adenosine. Real time PCR was used to determine the expression of genes. Results: SREBP1-c and A1 gene increased significantly in fatty diet (P=0. 016, and P=0. 019, respectively), HIIT and aerobic training had a significant effect on the reduction of SREBP1-c and A1 gene expression (P=0. 003, and P=0. 001, respectively). SREBP1-c and A1 in the adenosine injection group had a significant decrease (P=0. 004, and P=0. 002, respectively). The interaction of endurance training-adenosine had a significant decrease in the expression of A1 (P=0. 004) comparing to HIIT-Adenosine training (P=0. 019). Conclusion: Regardless of the intensity of exercise as an effective factor in the expression of lipogenesis genes, the adenosine dosage with increasing or decreasing its receptor (A1) following consumption of a High fat diet may have a significant role in the lipogenic expression of genes.

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APA: Copy

Hedayati katooli, A., AZARBAYJANI, M.A., BANAEIFAR, A., & ARSHADI, S.. (2019). The Effect of Aerobic Training and Adenosine on the Expression of SREBP-1C and A1 Receptor in Hepatic Fat-fed Rats. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 14(1 ), 1-9. SID. https://sid.ir/paper/363812/en

Vancouver: Copy

Hedayati katooli A., AZARBAYJANI M.A., BANAEIFAR A., ARSHADI S.. The Effect of Aerobic Training and Adenosine on the Expression of SREBP-1C and A1 Receptor in Hepatic Fat-fed Rats. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2019;14(1 ):1-9. Available from: https://sid.ir/paper/363812/en

IEEE: Copy

A. Hedayati katooli, M.A. AZARBAYJANI, A. BANAEIFAR, and S. ARSHADI, “The Effect of Aerobic Training and Adenosine on the Expression of SREBP-1C and A1 Receptor in Hepatic Fat-fed Rats,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 14, no. 1 , pp. 1–9, 2019, [Online]. Available: https://sid.ir/paper/363812/en

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