Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats

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JOKAR MASOUD; ZAREI FATEMEH; SHERAFATI MOGHADAM MOHAMMAD; ALIZADEH PALAVANI HAMED

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2020 | Volume:28 | Issue:6 Page(s): 2755-2765

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Title

Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats

Author(s)

JOKAR MASOUD | ZAREI FATEMEH | SHERAFATI MOGHADAM MOHAMMAD | ALIZADEH PALAVANI HAMED | Issue Writer Certificate

Keywords

Adipose tissueQ2

Endurance trainingQ1

mTOR proteinQ1

SREBP1 proteinQ1

Type 2 diabeticQ2

Abstract

Introduction: The mTOR and SREBP1 proteins play an important role important in the regulation and metabolism of Adipose tissue that can be activated through the mTORC1 pathway. The purpose of the present study was to investigate the effect of 8 weeks Endurance training on the content of mTOR and SREBP1 proteins in subcutaneous fat tissue in obese Type 2 diabetic male Sprague-Dawley rats. Methods: In this experimental study, 16 three-month-old Sprague-Dawley rats with a mean weight of 300± 20 g were selected. After diabetic induction with Streptozotocin and Nicotinamide, rats were randomly assigned to two groups, diabetic training (n=8) and diabetic control (n=8). The training group trained for 4 days a week in accordance with the training program for 8 weeks, while the control group did not have any training program. The independent t-test in SPSS software ver. 19 was used to analyze the data. Results: There was a significant increase in the content of mTOR (p<0. 0001) and SREBP1 (p<0. 0001) proteins in the training group compared to control; The control group weight increased (p<0. 003) and training group (p<0. 002) significantly decreased at the end of the eighth week compared to the first week. The blood glucose increased in the control group (p<0. 001) and decreased in the exercise group (p<0. 0001) in the eighth week compared to the first week. Conclusion: Endurance training can adjust the weight, blood glucose and proteins content of mTOR and SREBP1; Therefore, Endurance training can be an important factor in controlling and regulating fat tissue metabolism; this type of training can be effective for obese subjects with type 2 diabetes.

Cites

The Effect of Ampk and P53 Proteins On Tor Pathway Following Endurance Training In The Left Ventricle Of The Heart Of Diabetic Rats By Streptozotocin And Nicotinamide

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APA: Copy

JOKAR, MASOUD, ZAREI, FATEMEH, SHERAFATI MOGHADAM, MOHAMMAD, & ALIZADEH PALAVANI, HAMED. (2020). Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 28(6 ), 2755-2765. SID. https://sid.ir/paper/402220/en

Vancouver: Copy

JOKAR MASOUD, ZAREI FATEMEH, SHERAFATI MOGHADAM MOHAMMAD, ALIZADEH PALAVANI HAMED. Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(6 ):2755-2765. Available from: https://sid.ir/paper/402220/en

IEEE: Copy

MASOUD JOKAR, FATEMEH ZAREI, MOHAMMAD SHERAFATI MOGHADAM, and HAMED ALIZADEH PALAVANI, “Effect of 8-Week Endurance Training on the Content of Mtor and SREBP1 Proteins in Subcutaneous Fat Tissue in Obese Type 2 Diabetic Male Sprague-Dawley Rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 6 , pp. 2755–2765, 2020, [Online]. Available: https://sid.ir/paper/402220/en

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