Effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats

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Shahavand h.; HOSSEINPOUR DELAVAR S.; Behpur n.; SAFIKHANI H.; AZIZI M.

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Journal: Yafteh Year:2021 | Volume:22 | Issue:4 (86) Page(s): 25-36

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Title

Effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats

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Keywords

TrainingQ1

ANGPT-1Q1

TOSQ1

HeartQ2

DiabetesQ2

Abstract

Background: Patients with Diabetes mellitus are at high risk of antioxidants and in long-term vascular lesions. Therefore, the aim of the present study was to evaluate the effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats. Materials and Methods: 30 male Wistar rats were divided into 3 groups (n= 10) diabetic Training, diabetic control and healthy control groups. Animals in diabetic groups were diabetic by intraperitoneal injection of streptozotocin. The exercise program consisted of 6 weeks of treadmill Training. 24 hours after the last Training session to evaluate the effect of exercise, cardiac tissue samples were extracted to measure gene expression of ANGPT-1 and total oxidative status. One-way ANOVA with statistical level (P<0. 05) was used to compare the differences between groups. Results: The results showed that gene expression of ANGPT-1 and TOS were significantly increased in the diabetic Training group compared to the diabetic control group (P= 0. 001) but only in the ANGPT-1 there were no significant differences (P= 0. 001) between two groups of diabetic control and healthy control (P>0. 05). Conclusion: It seems that endurance Training has a positive effect on the expression of ANGPT-1 gene and improves the overall antioxidant status of the Heart tissue of diabetic rats and improve the diabetic Heart.

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APA: Copy

Shahavand, h., HOSSEINPOUR DELAVAR, S., Behpur, n., SAFIKHANI, H., & AZIZI, M.. (2021). Effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats. YAFTEH, 22(4 (86) ), 25-36. SID. https://sid.ir/paper/364032/en

Vancouver: Copy

Shahavand h., HOSSEINPOUR DELAVAR S., Behpur n., SAFIKHANI H., AZIZI M.. Effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats. YAFTEH[Internet]. 2021;22(4 (86) ):25-36. Available from: https://sid.ir/paper/364032/en

IEEE: Copy

h. Shahavand, S. HOSSEINPOUR DELAVAR, n. Behpur, H. SAFIKHANI, and M. AZIZI, “Effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats,” YAFTEH, vol. 22, no. 4 (86) , pp. 25–36, 2021, [Online]. Available: https://sid.ir/paper/364032/en

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