The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ganjkhanlou Zahra; SIRATI SABET MAJID; SALAMI SIAMAK; MIRFAKHRAIE REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2020 | Volume:24 | Issue:1 Page(s): 48-55

Download Full-Text

Persian Verion

View:

496

Download:

Cites:

Information Journal Paper

Title

The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer

Author(s)

Ganjkhanlou Zahra | SIRATI SABET MAJID | SALAMI SIAMAK | MIRFAKHRAIE REZA | Issue Writer Certificate

Keywords

Gene expressionQ2

MCF7Q1

MDA-MB 231Q1

MMP1Q1

QuinacrineQ1

Abstract

Background: Breast cancer is the most frequent malignancy in women worldwide and occurs when cells in the breast begin to grow out of control. Matrix metalloproteinases (MMP), including MMP1 protein, are important in the progression of various types of cancer. Quinacrine, a derivative of 9-aminoacridine, has been shown to inhibit the growth of several types of cancer cells. In this study, we examined the effect of Quinacrine on MMP1 Gene expression in breast cancer cell lines MDA-MB 231 and MCF7. MDA-MB 231 cell line has triple negative breast cancer cells properties. Materials and Methods: Breast cancer cell lines, MDA-MB 231 and MCF7, were treated with 0. 5 μ M Quinacrine for 3 days. The dose was selected using MTT assay. Expression of MMP1 gene was quantified by Real-time PCR. Significance of observations were statistically checked by t-test using P<0. 05 as the level of significance. Results: Quinacrine did not have meaningful effect on MMP1 Gene expression on MDAMB 231 and MCF7 cell lines in 0. 5 μ M concentration for 72 hours. Conclusion: MMP1 gene is important in metastasis and the present study showed that Quinacrine could not affect the expression of this gene on these breast cancer cell lines.

Cites

No record.

References

Cite

APA: Copy

Ganjkhanlou, Zahra, SIRATI SABET, MAJID, SALAMI, SIAMAK, & MIRFAKHRAIE, REZA. (2020). The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer. FEYZ, 24(1 ), 48-55. SID. https://sid.ir/paper/364518/en

Vancouver: Copy

Ganjkhanlou Zahra, SIRATI SABET MAJID, SALAMI SIAMAK, MIRFAKHRAIE REZA. The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer. FEYZ[Internet]. 2020;24(1 ):48-55. Available from: https://sid.ir/paper/364518/en

IEEE: Copy

Zahra Ganjkhanlou, MAJID SIRATI SABET, SIAMAK SALAMI, and REZA MIRFAKHRAIE, “The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer,” FEYZ, vol. 24, no. 1 , pp. 48–55, 2020, [Online]. Available: https://sid.ir/paper/364518/en

Related Journal Papers