Neuroprotective Effects of Myricitrin on Cognitive Deficits in Hippacampal Demyelinated Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Sargolzaee Javan Fatemeh; MIRSHEKAR MOHAMMADALI; SHAHRAKI MOHAMMADREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:29 | Issue:180 Page(s): 8-23

Download Full-Text

Persian Verion

View:

302

Download:

Cites:

Information Journal Paper

Title

Neuroprotective Effects of Myricitrin on Cognitive Deficits in Hippacampal Demyelinated Rats

Author(s)

Sargolzaee Javan Fatemeh | MIRSHEKAR MOHAMMADALI | SHAHRAKI MOHAMMADREZA | Issue Writer Certificate

Keywords

Multiple sclerosisQ2

MyricitrinQ1

antioxidantQ2

cognitionQ1

ethidium bromideQ2

Abstract

Background and purpose: Multiple sclerosis (MS) as an autoimmune disease is the most common demyelinating inflammatory disease in young people that affects the central nervous system. Myricitrin (MYR) is known to have antioxidant and neuroprotection effects, so, the current study investigated its effect on cognitive defects in rat models of MS. Materials and methods: In this experimental study, 40 Wistar rats were divided into five groups. Intra-hippocampus injection of ethidium bromide (3 µ L 0. 01%) was performed using Hamilton syringe to induce demyelination. MYR was injected intraperitoneally for seven days after induction of demyelination. Measurements of passive avoidance memory in shuttle box, spatial memory (using Morris water maze), balance (by rotarod task), and anxiety level (using elevated plus maze) were done. The levels of MDA, TNF-α , and total antioxidant capacity were also measured. Results: ethidium bromide significantly increased hippocampal MDA and TNF-α levels and decreased hippocampal total antioxidant capacity activity (P< 0. 001). MYR treatment significantly prevented the decrease of antioxidant capacity and the increase in hippocampal MDA and TNF-α levels induced by ethidium bromide (P< 0. 05 and P< 0. 001, respectively). Behavioral evaluation also indicated that treatment with MYR significantly improved the ability to keep information and reminders, spatial memory, balance, and anxiety. Conclusion: Injection of ethidium bromide into the CA1 region of the hippocampus led to the induction of MS, and administration of MYR may improve memory, motor function, and anxiety in MS models, possibly through antioxidant and anti-inflammatory pathways.

Cites

No record.

References

No record.

Cite

APA: Copy

Sargolzaee Javan, Fatemeh, MIRSHEKAR, MOHAMMADALI, & SHAHRAKI, MOHAMMADREZA. (2020). Neuroprotective Effects of Myricitrin on Cognitive Deficits in Hippacampal Demyelinated Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(180 ), 8-23. SID. https://sid.ir/paper/364606/en

Vancouver: Copy

Sargolzaee Javan Fatemeh, MIRSHEKAR MOHAMMADALI, SHAHRAKI MOHAMMADREZA. Neuroprotective Effects of Myricitrin on Cognitive Deficits in Hippacampal Demyelinated Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(180 ):8-23. Available from: https://sid.ir/paper/364606/en

IEEE: Copy

Fatemeh Sargolzaee Javan, MOHAMMADALI MIRSHEKAR, and MOHAMMADREZA SHAHRAKI, “Neuroprotective Effects of Myricitrin on Cognitive Deficits in Hippacampal Demyelinated Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 180 , pp. 8–23, 2020, [Online]. Available: https://sid.ir/paper/364606/en

Related Journal Papers