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Information Journal Paper

Title

The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats

Pages

  190-200

Abstract

 Background Acute and chronic effects of Nitric oxide on Oxidative stress and neuronal demyelination have been reported in human and animal models. Objective Oxidative stress is involved in the pathogenesis of demyelinated animals; thus, this study investigated the effects of Nitric oxide system and Ethidium bromide on Oxidative stress in the hippocampal formation. Methods This experimental study was performed on eight groups of male rats, as follows: control, control, Ethidium bromide, L-Arginine, L-NAME, Ethidium bromide + L-Arginine, Ethidium bromide + L-NAME, and Ethidium bromide + L-Arginine + L-NAME. Three days after the injection of drugs into the hippocampal CA1 area, hippocampal biopsy was performed, and Oxidative stress parameters were measured in this area. One-way analysis of variance (ANOVA) and posthoc tests were used for data analysis. Findings Injection of 3 μ L Ethidium bromide into the CA1 region increased Oxidative stress parameters (P<0. 01). Injection of 15. 3 μ g/rat L-Arginine in this region stopped the response of Ethidium bromide (P<0. 05, P<0. 01); while, the injection of 15. 1 μ g/rat L-NAME failed to return the effects of the Ethidium bromide. Moreover, the combination of 15. 3 μ g/rat L-Arginine and 15. 1 μ g/rat L-NAME only returned lipid peroxidation caused by the injection of 3 μ L of Ethidium bromide to normal (P<0. 05); this process failed to improve antioxidant enzymes. Conclusion The obtained results suggested the excitatory effect of the Nitric oxide system on alleviating Oxidative stress induced by Ethidium bromide in the CA1 region of male rats.

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    APA: Copy

    RAhimluoye Marjani, Zahedeh, Alihemati, Ali Reza, HATAMI NEMATI, HOMEIRA, & AHMADI, HATAM. (2019). The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 23(3 (104) ), 190-200. SID. https://sid.ir/paper/49107/en

    Vancouver: Copy

    RAhimluoye Marjani Zahedeh, Alihemati Ali Reza, HATAMI NEMATI HOMEIRA, AHMADI HATAM. The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;23(3 (104) ):190-200. Available from: https://sid.ir/paper/49107/en

    IEEE: Copy

    Zahedeh RAhimluoye Marjani, Ali Reza Alihemati, HOMEIRA HATAMI NEMATI, and HATAM AHMADI, “The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 3 (104) , pp. 190–200, 2019, [Online]. Available: https://sid.ir/paper/49107/en

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