COMPARING THE EFFECTS OF NITRAZPAM AND ACTH IN INFANTILE SPASMS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAGHDIRI M.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2003 | Volume:7 | Issue:4 (30) Page(s): 349-354

Download Full-Text

Persian Verion

View:

1,501

Download:

Cites:

Information Journal Paper

Title

COMPARING THE EFFECTS OF NITRAZPAM AND ACTH IN INFANTILE SPASMS

Author(s)

TAGHDIRI M.M. | Issue Writer Certificate

Keywords

INFANTILE SPASMSQ4

EPILEPSYQ3

NITRAZEPAMQ4

ACTHQ4

Abstract

Background: Among different epileptic syndromes INFANTILE SPASMS (I.S) or West syndrome is considered as the most malignant one which causes irreparable brain damage in the child. Consequently the longer this type of EPILEPSY lasts, the more harmful results will follow. Currently common treatment include drugs such as ACTH, prednisolone, valporic acid and benzodiazepines. Materials and methods: In a randomized control double blind trial, we study 60 children aged 224 months who had IS and were admitted in Mofid Hospital, during a two year period, 1998-2000. In our study patients were assigned randomly in two groups: NITRAZEPAM (0.5-1 mg/kg/24h, in three divided doses taken with meals, and ACTH (40 U/daily/IM, single dose). At the end of the second, forth and sixth week of the treatment, patients were evaluated for complete control or reduction of seizure and drug side effects. Results: Result revealed that at the end of the sixth week of treatment 63% of NZP- and 30% of ACTH-treated patients had complete seizure control (p<0.05). Following the 6th week the relative reduction of seizure frequency was observed in 26% of NZP and 53% of ACTH group (NS). Complete normalization of EEG was reported in 47% and 30% of the NZP and ACTH group, respectively. Conclusion: This study vividly cleared the fact that NZP has less and negligible side effect compared to ACTH. Considering the better therapeutic effects, fewer side effects and lower cost, NZP is the drug of choice in IS.

Cites

No record.

References

No record.

Cite

APA: Copy

TAGHDIRI, M.M.. (2003). COMPARING THE EFFECTS OF NITRAZPAM AND ACTH IN INFANTILE SPASMS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 7(4 (30)), 349-354. SID. https://sid.ir/paper/365115/en

Vancouver: Copy

TAGHDIRI M.M.. COMPARING THE EFFECTS OF NITRAZPAM AND ACTH IN INFANTILE SPASMS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2003;7(4 (30)):349-354. Available from: https://sid.ir/paper/365115/en

IEEE: Copy

M.M. TAGHDIRI, “COMPARING THE EFFECTS OF NITRAZPAM AND ACTH IN INFANTILE SPASMS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 7, no. 4 (30), pp. 349–354, 2003, [Online]. Available: https://sid.ir/paper/365115/en

Related Journal Papers