EFFECT OF ORAL VITAMIN E SUPPLEMENT IN TYPE II DIABETIC MELLITUS PATIENTS

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BOSHTAM M.; RAFIEI M.; SARAFZADEGAN NAZILA; GOLSHADI I.; ANI M.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2003 | Volume:10 | Issue:4 (Supplement On Diabetes) Page(s): 32-40

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Title

EFFECT OF ORAL VITAMIN E SUPPLEMENT IN TYPE II DIABETIC MELLITUS PATIENTS

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Keywords

TYPE II DIABETES MELLITUSQ3

INSULINQ2

GLYCATED HEMOGLOBIRIQ2

VITAMIN EQ2

FASTING BLOOD SUGARQ3

BLOOD LIPIDSQ3

Abstract

Prevalence of diabetes mellitus as a major cardiovascular risk factors are increasing in Isfahan urban population. On the other hand, this disease has unfavorable effects on other sites of the body. So, it is necessary to find any way for controlling this disease. This triple blind placebo-controlled clinical trial was performed aimed to determine the effects of antioxidant VITAMIN E on FASTING BLOOD SUGAR (FBS), serum INSULIN and glycated hemoglobin (GHb) in patients with type II diabetes (NIDDM). Diabetic group included 100 patients with uncomplicated NIDDM. The subjects were age4 20-60 years with only one cardiovascular risk factor (diabetes) Drug and placebo groups were the same in age, sex, education and job. They were randomly selected among diabetic patients from Diabetes Clinics in Isfahan Human Service. The subjects were divided in to two randomized subgroups of drug or placebo. Drug subgroups were received VITAMIN E as 200 IV/day pills and placebo subgroup was only received placebo. At the beginning and the end of the study, the VITAMIN E level was measured in all subjects. Fasting blood and blood sugar (FBS), serum INSULIN and glycated hemoglobin, (GHb) were assayed in two groups. These measurements were done at the beginning, during and at the end study. Also, serum total cholesterol (T.cho) and triglycerids were measured in diabetic patients. Serum lipids, FBS, INSULIN and GHb were measured by ELAN 2000 autoanalyzer in the laboratory of Isfahan cardiovascular Research Center. VITAMIN E was assayed according to Hansen & Warwick methoed by florimetry method. At the end of the study, it was found that in patients with TYPE II DIABETES MELLITUS there was no positive effect as GHb did not change and FBS level decreased nonsignificantly (-4.3% versus -14.0% in placebo group). Also, serum INSULIN level showed an increase (p=0.15). Also, serum lipids did not show any change in two groups during study. Finally, it is concluded that in patients with type II diabetes the obtained results did not show any beneficial effect of the VITAMIN E during this period. But regarding the effects of this vitamin on other factors in the diabetic people, the prescription of VITAMIN E supplement can not be avoided and even we can no conclude it to be ineffective for diabetic patients because it needs more extensive studies.

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APA: Copy

BOSHTAM, M., RAFIEI, M., SARAFZADEGAN, NAZILA, GOLSHADI, I., & ANI, M.. (2003). EFFECT OF ORAL VITAMIN E SUPPLEMENT IN TYPE II DIABETIC MELLITUS PATIENTS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 10(4 (Supplement On Diabetes)), 32-40. SID. https://sid.ir/paper/36525/en

Vancouver: Copy

BOSHTAM M., RAFIEI M., SARAFZADEGAN NAZILA, GOLSHADI I., ANI M.. EFFECT OF ORAL VITAMIN E SUPPLEMENT IN TYPE II DIABETIC MELLITUS PATIENTS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;10(4 (Supplement On Diabetes)):32-40. Available from: https://sid.ir/paper/36525/en

IEEE: Copy

M. BOSHTAM, M. RAFIEI, NAZILA SARAFZADEGAN, I. GOLSHADI, and M. ANI, “EFFECT OF ORAL VITAMIN E SUPPLEMENT IN TYPE II DIABETIC MELLITUS PATIENTS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 4 (Supplement On Diabetes), pp. 32–40, 2003, [Online]. Available: https://sid.ir/paper/36525/en

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