THE EFFECTS OF TOTAL EXTRACT OCIMUMBASILICUMON VEGF GENE EXPRESSION CHANGES IN CHICK EMBRYO CHORIOALLANTOIC MEMBRANE ANGIOGENESIS

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NIAZI FATEMEH; SHAHROKH ABADI KHADIJEH; TEHRANIPOUR MARYAM

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:8 Page(s): 629-640

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Title

THE EFFECTS OF TOTAL EXTRACT OCIMUMBASILICUMON VEGF GENE EXPRESSION CHANGES IN CHICK EMBRYO CHORIOALLANTOIC MEMBRANE ANGIOGENESIS

Author(s)

NIAZI FATEMEH | SHAHROKH ABADI KHADIJEH | TEHRANIPOUR MARYAM | Issue Writer Certificate

Keywords

ANGIOGENESISQ2

VEGFQ1

OCIMUMBASILICUMQ1

CHORIOALLANTOIC MEMBRANEQ1

Abstract

Introduction: ANGIOGENESIS is one of the most important biological processes that any disruption of it can cause diseases. The main point of the molecular guidance in this process is the vascular endothelial growth factor (VEGF) that acts through its receptors and is one of the ANGIOGENESIS specific regulators. This study aimed to investigate the effect ofOcimumbasilicum aqueous and alcoholic extract on VEGF gene expression changes in chick CHORIOALLANTOIC MEMBRANE.Methods: In this empirical study, 60 Ross fertilized eggs were randomly divided into 6 groups, including control group, sham-exposed group, and 4 experimental groups. On the second day of incubation, a window was opened on the eggs and on the eighth day 50 and 150 mg/kg of basil aqueous and alcoholic extracts were injected into the chick CHORIOALLANTOIC MEMBRANE (CAM). On the twelfth day, for RNA extraction and VEGF gene expression examination the CHORIOALLANTOIC MEMBRANE was sampled, then cDNA was synthesized and VEGF gene expression changes were studied using quantitative data analysis in all groups.Results: The results showed that VEGF gene expression- under the influence of aqueous and alcoholic extracts of basil- increased in all experimental groups compared to the sham group, but the rise was more in those groups, which were treated with aqueous extract, in both dosages, than alcoholic extract-treated groups.Conclusion: Both aqueous and alcoholic extracts of basil increased VEGF gene expression. The study showed an increase in the number and length of vessels. According to the increasing effects, basil aqueous and alcoholic extracts can affect the molecular processes of growth and dependent processes.

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APA: Copy

NIAZI, FATEMEH, SHAHROKH ABADI, KHADIJEH, & TEHRANIPOUR, MARYAM. (2017). THE EFFECTS OF TOTAL EXTRACT OCIMUMBASILICUMON VEGF GENE EXPRESSION CHANGES IN CHICK EMBRYO CHORIOALLANTOIC MEMBRANE ANGIOGENESIS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(8 ), 629-640. SID. https://sid.ir/paper/36544/en

Vancouver: Copy

NIAZI FATEMEH, SHAHROKH ABADI KHADIJEH, TEHRANIPOUR MARYAM. THE EFFECTS OF TOTAL EXTRACT OCIMUMBASILICUMON VEGF GENE EXPRESSION CHANGES IN CHICK EMBRYO CHORIOALLANTOIC MEMBRANE ANGIOGENESIS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(8 ):629-640. Available from: https://sid.ir/paper/36544/en

IEEE: Copy

FATEMEH NIAZI, KHADIJEH SHAHROKH ABADI, and MARYAM TEHRANIPOUR, “THE EFFECTS OF TOTAL EXTRACT OCIMUMBASILICUMON VEGF GENE EXPRESSION CHANGES IN CHICK EMBRYO CHORIOALLANTOIC MEMBRANE ANGIOGENESIS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 8 , pp. 629–640, 2017, [Online]. Available: https://sid.ir/paper/36544/en

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