ANTI-PROLIFERATIVE EFFECTS OF HYDRALAZINE ON K562 CELL LINE (CML)

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DADAKHANI SONYA; PAZHANG YAGHUB; IMANI MEHDI

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Title

ANTI-PROLIFERATIVE EFFECTS OF HYDRALAZINE ON K562 CELL LINE (CML)

Author(s)

DADAKHANI SONYA | PAZHANG YAGHUB | IMANI MEHDI | Issue Writer Certificate

Keywords

HYDRALAZINEQ2

DNA METHYLTRANSFERASEQ1

K562 CELL LINEQ1

ANTI-TUMOR EFFECTSQ1

Abstract

Introduction: Cancer is the second leading cause of death in the world and among the types of cancer, leukemia is one of the deadliest. Chronic myeloid leukemia (CML) is the best known types of leukemia. HYDRALAZINE is in the cardiovascular medical group, which is considering as inhibitory factor on the proliferation of cancer cells by knowing its inhibitory effects on DNA METHYLTRANSFERASE. The purpose of this study was to evaluate the inhibitory effects of HYDRALAZINE on K562 cells proliferation.Methods: First, the K562 cells were cultured. After, the different concentrations of the HYDRALAZINE were prepared and the cells were treated for 24, 48 and 72 hours. Next, the inhibitory effects of this drug on K562 cells proliferation was measured by MTT assay. Hoechst (33342) staining and DNA electrophoresis was used to check apoptosis. Data analyses were performed using SPSS software (Version 20) and ANOVA test (P<0.05).Results: MTT assay results showed that HYDRALAZINE has the highest cytotoxic activity in 80μM at 72 hours. Drug IC50 was obtained 81 micromolar. And also the results of Hoechst staining and DNA electrophoresis showed that HYDRALAZINE was caused apoptosis.Conclusion: In the present study, it was shown that HYDRALAZINE induces cells death by apoptosis and this effect was dose-dependent and treat time dependent. It is suggested that more studies will be done on the effects of this drug on animal models and human.

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APA: Copy

DADAKHANI, SONYA, PAZHANG, YAGHUB, & IMANI, MEHDI. (2017). ANTI-PROLIFERATIVE EFFECTS OF HYDRALAZINE ON K562 CELL LINE (CML). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(8 ), 670-680. SID. https://sid.ir/paper/36545/en

Vancouver: Copy

DADAKHANI SONYA, PAZHANG YAGHUB, IMANI MEHDI. ANTI-PROLIFERATIVE EFFECTS OF HYDRALAZINE ON K562 CELL LINE (CML). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(8 ):670-680. Available from: https://sid.ir/paper/36545/en

IEEE: Copy

SONYA DADAKHANI, YAGHUB PAZHANG, and MEHDI IMANI, “ANTI-PROLIFERATIVE EFFECTS OF HYDRALAZINE ON K562 CELL LINE (CML),” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 8 , pp. 670–680, 2017, [Online]. Available: https://sid.ir/paper/36545/en

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