Assessment of adherence to antituberculosis drug regimen among patients receiving isoniazid, rifampin and pyrazinamide: Kerman, Iran

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Sohrevardi Seyyed Mojtaba; SARRAFZADEH FARHAD; KHOSRAVI ALI; Hassanzadeh Abdolreza

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:27 | Issue:3 Page(s): 1395-1404

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Title

Assessment of adherence to antituberculosis drug regimen among patients receiving isoniazid, rifampin and pyrazinamide: Kerman, Iran

Author(s)

Sohrevardi Seyyed Mojtaba | SARRAFZADEH FARHAD | KHOSRAVI ALI | Hassanzadeh Abdolreza | Issue Writer Certificate

Keywords

TuberculosisQ3

Drug adherenceQ1

IsoniazidQ2

RifampinQ3

PyrazinamideQ1

Abstract

Introdution: Among infectious diseases, Tuberculosis is one of the leading causes of death killing in nearly 1. 5 million people yearly. Considering the importance of patient co-operation in drug therapy and resistance we decided to evaluate the rate of co-operation of Tuberculosis infected patients in regard to their use of antiTuberculosis drugs in Kerman. Methods: This descriptive study was conducted as a sectional and census study and 80 patients succeeded to finalize it. Demographic information was collected through a questionnaire by patients. To carry out the designed test, a urinary sample was taken from each patient and a few drops of each were added to the drugspecific reagents. On the basis of color variation which is special for Rifampin, Isoniazid and Pyrazinamide, we made a decision on the co-operation of the patients. The collected data were analyzed by the the use of SPSS software version 18 and p-value<0. 05 was acceptable. To find out the relation between variables, the Chi-square test was applied. Results: The results of this study showed that the total co-operation rate for patients administered with Isoniazid was 70%, Rifampin 70%, and pirazinamide 68. 1%. The quality of adherence to drug orders with age, knowledge of unwanted adverse effects, opium addiction and duration of drug use had a significant relationship (P <0. 05); but with gender, duration of illness, use of another drug, and the presence of another TB infected in the family, no significant difference was observed. Conclusion: We resulted those factors such as age, addiction and lifestyle, duration of treatment and awareness of side effects influence on the co-operation of the patients on drug usage. So that people over 35 years, addict ones, treated for a long time and in the patients with lack of awareness of drug side effects, their adherence to the treatment regimen was lower.

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References

FDA-Approved Drugs That Interfere With Laboratory Tests: A Systematic Search Of U. S. Drug Labels

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APA: Copy

Sohrevardi, Seyyed Mojtaba, SARRAFZADEH, FARHAD, KHOSRAVI, ALI, & Hassanzadeh, Abdolreza. (2019). Assessment of adherence to antituberculosis drug regimen among patients receiving isoniazid, rifampin and pyrazinamide: Kerman, Iran. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(3 ), 1395-1404. SID. https://sid.ir/paper/36587/en

Vancouver: Copy

Sohrevardi Seyyed Mojtaba, SARRAFZADEH FARHAD, KHOSRAVI ALI, Hassanzadeh Abdolreza. Assessment of adherence to antituberculosis drug regimen among patients receiving isoniazid, rifampin and pyrazinamide: Kerman, Iran. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(3 ):1395-1404. Available from: https://sid.ir/paper/36587/en

IEEE: Copy

Seyyed Mojtaba Sohrevardi, FARHAD SARRAFZADEH, ALI KHOSRAVI, and Abdolreza Hassanzadeh, “Assessment of adherence to antituberculosis drug regimen among patients receiving isoniazid, rifampin and pyrazinamide: Kerman, Iran,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 3 , pp. 1395–1404, 2019, [Online]. Available: https://sid.ir/paper/36587/en

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