Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line

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KAZEMI LOMEDASHT FATEMEH; BEHDANI MAHDI; SHAHBAZZADEH DELAVAR

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Journal: Razi Journal of Medical Sciences Year:2020 | Volume:26 | Issue:10 Page(s): 1-7

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Title

Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line

Author(s)

KAZEMI LOMEDASHT FATEMEH | BEHDANI MAHDI | SHAHBAZZADEH DELAVAR | Issue Writer Certificate

Keywords

Hemiscorpius lepturusQ1

Breast cancerQ2

T47DQ1

Cytotoxic effectQ2

Abstract

Background: Breast cancer is one of the most related cancer deaths among women. The scorpion venom consists of various peptides and proteins with cytotoxic, apoptotic and growth inhibitory effects on various cancers. Studying the Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D Breast cancer cell line was the main aim of this study. Methods: The T47D cells were cultured as monolayer in RPMI1640 medium. The toxicity of the scorpion venom on T47D cell line was evaluated by MTT assay and the IC50 was calculated. The HEK293 cell line was used as control cell line. Results: The MTT assay results showed the time and dose-dependent inhibitory effect of H. lepturus venom on T47D cell line. However, such effect was not observed on HEK293 cell line in identical dose. Conclusion: The achieved results indicate the anticancer effect of H. lepturus venom on T47D Breast cancer cell line.

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APA: Copy

KAZEMI LOMEDASHT, FATEMEH, BEHDANI, MAHDI, & SHAHBAZZADEH, DELAVAR. (2020). Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(10 ), 1-7. SID. https://sid.ir/paper/365906/en

Vancouver: Copy

KAZEMI LOMEDASHT FATEMEH, BEHDANI MAHDI, SHAHBAZZADEH DELAVAR. Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2020;26(10 ):1-7. Available from: https://sid.ir/paper/365906/en

IEEE: Copy

FATEMEH KAZEMI LOMEDASHT, MAHDI BEHDANI, and DELAVAR SHAHBAZZADEH, “Cytotoxic effect Hemiscorpius lepturus scorpion venom on T47D breast cancer cell line,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 10 , pp. 1–7, 2020, [Online]. Available: https://sid.ir/paper/365906/en

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