The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone)

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Adiyani P.; ABBASSI DALOII A.; SHADMEHRI S.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2020 | Volume:9 | Issue:4 Page(s): 1903-1912

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Title

The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone)

Author(s)

Adiyani P. | ABBASSI DALOII A. | SHADMEHRI S. | Issue Writer Certificate

Keywords

Aerobic trainingQ1

BoldenoneQ1

L-carnitineQ1

TNF-αQ1

IL-1βQ1

Abstract

Background & Objective: The aim of this study was to investigate the effect of endurance training and L-carnitine consumption on TNF-a and IL-1β gene expression of heart tissue in Wistar male rats following anabolic steroid consumption (Boldenone). Materials & Methods: In this experimental study, 30 male Wistar rats aged 12 weeks (weight 195± 7. 94g) were randomly divided into five groups including control, no-treatment, Boldenone (5mg/kg), L-carnitine and Aerobic training-L-carnitine. The endurance moderate intensity training program (55-50% of maximal oxygen consumption) was performed for 6 weeks and 5 times a week. Injection was conducted once a week, on an appointed day, and in the quadriceps and hamstring it was conducted in depth. After anesthesia, autopsy was performed and the heart was isolated. The TNF-α and IL-1β gene expression in the samples was measured by Real Time PCR. Data were analyzed using t-test, One-way ANOVA and post hoc Scheffe at the significant level of P<0. 05. Results: The results showed that there was a significant difference between the mean TNF-α and IL-1β gene expression of heart tissue in male Wistar rats in different groups (P=0. 001). The changes in TNF-α and IL-1β gene expression of heart tissue in L-carnitine and Training-L-carnitine groups were significantly lower than those of the no-treatment and boldenon groups (P=0. 001). Conclusion: It seems that supplementation of L-carnitine with regular Aerobic training reduces heart tissue damage induced by anabolic androgenic steroids.

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APA: Copy

Adiyani, P., ABBASSI DALOII, A., & SHADMEHRI, S.. (2020). The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone). JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 9(4 ), 1903-1912. SID. https://sid.ir/paper/366083/en

Vancouver: Copy

Adiyani P., ABBASSI DALOII A., SHADMEHRI S.. The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone). JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;9(4 ):1903-1912. Available from: https://sid.ir/paper/366083/en

IEEE: Copy

P. Adiyani, A. ABBASSI DALOII, and S. SHADMEHRI, “The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone),” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 9, no. 4 , pp. 1903–1912, 2020, [Online]. Available: https://sid.ir/paper/366083/en

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