Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province

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Shahsavari Ronak; KESHAVARZI FATEMEH

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:7 Page(s): 1-9

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Title

Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province

Author(s)

Shahsavari Ronak | KESHAVARZI FATEMEH | Issue Writer Certificate

Keywords

Type 2 diabetesQ2

PolymorphismQ2

ATF6 (rs2070150)Q1

Abstract

Background: Type 2 diabetes is a metabolic disorder. Various genetic locations play a role in susceptibility to this disease, including those in the ATF6 (Activating transcription factor. The aim of this study was to investigate the correlation between ATF6 Polymorphism (rs2070150) and Type 2 diabetes mellitus in patients with Type 2 diabetes in Kurdistan. Methods: The present study is a case-control study. A total of 200 blood samples 100 healthy individuals and 100 diabetic patients (age and gender matched)) from the cities of Kurdistan province were screening for ATF6 (rs2070150) Polymorphism by Tetra-ARMs PCR method. The obtained data were analyzed using SPSS software and chi-square test. Results: The results showed that 4, 12 and 84 patients, and 3, 26 and 71 healthy controls, respectively, had CC, CG and GG genotypes. Conclusion: GC (%42) Genotype in studied population is a risk factor for Type 2 diabetes (p=0. 041).

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References

Profiles of circulating miRNAs following metformin treatment in patients with type 2 diabetes

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APA: Copy

Shahsavari, Ronak, & KESHAVARZI, FATEMEH. (2019). Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(7 ), 1-9. SID. https://sid.ir/paper/366525/en

Vancouver: Copy

Shahsavari Ronak, KESHAVARZI FATEMEH. Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(7 ):1-9. Available from: https://sid.ir/paper/366525/en

IEEE: Copy

Ronak Shahsavari, and FATEMEH KESHAVARZI, “Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 7 , pp. 1–9, 2019, [Online]. Available: https://sid.ir/paper/366525/en

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