Resistance to Aminoglycosides among Methicillin Resistant Staphylococcus aureus Strains Isolated from Patients with Urinary Tract Infection in Isfahan, Iran 2017

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RAHIMI FATEH; Torabi Mina

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2019 | Volume:23 | Issue:83 Page(s): 17-24

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Title

Resistance to Aminoglycosides among Methicillin Resistant Staphylococcus aureus Strains Isolated from Patients with Urinary Tract Infection in Isfahan, Iran 2017

Author(s)

RAHIMI FATEH | Torabi Mina | Issue Writer Certificate

Keywords

AminoglycosidesQ2

MRSAQ1

UTIQ3

SCCmec typingQ1

Abstract

Background and objective: Aminoglycoside antibiotics are used to treat many Gram-negative and some Gram-positive infections. Among various bacterial species, resistance to AGs arises through a variety of intrinsic and acquired mechanisms, in which by far the most widespread mechanism of resistance to AGs is the inactivation of these antibiotics by AG-modifying enzymes. In this study, we aimed to determine the resistance to Aminoglycosides among methicillin resistant Staphylococcus aureus strains in Isfahan. Materials and methods: In this study a total of 286 S. aureus strains were isolated from patients with urinary infections in 2 hospitals in Isfahan during 2017 and identified using specific primers. The resistance of MRSA strains to 16 antibiotics was determined and presence of different SCCmec types and genes encoding resistance to Aminoglycosides was detected. Results: A total of 112 (39%) cefoxitin resistant and mecA positive S. aureus strains were identified among isolates. All MRSA strains were susceptible to vancomycin, linezolid and quinupristin/dalfopristin and showed high resistance to penicillin, ciprofloxacin, erythromycin and clindamycin. Moreover, 92, 89, 89, 86, 85 and 63% of strains were resistant to tobramycin, kanamycin, amikacin, neomycin and gentamicin, respectively. Ninety seven percent of strains harbored SCCmec type III and aac(6’ )-Ie+aph(2’ ), ant(4’ )-Ia, ant(6)-Ia and aph(3’ )-IIIa genes were detected among 63, 60, 56 and 38% of strains, respectively. Conclusion: High prevalence of resistance to Aminoglycosides among MRSA strains indicating the inefficiency of these antibiotics for treatment of urinary infections in this study.

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APA: Copy

RAHIMI, FATEH, & Torabi, Mina. (2019). Resistance to Aminoglycosides among Methicillin Resistant Staphylococcus aureus Strains Isolated from Patients with Urinary Tract Infection in Isfahan, Iran 2017. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 23(83 ), 17-24. SID. https://sid.ir/paper/366679/en

Vancouver: Copy

RAHIMI FATEH, Torabi Mina. Resistance to Aminoglycosides among Methicillin Resistant Staphylococcus aureus Strains Isolated from Patients with Urinary Tract Infection in Isfahan, Iran 2017. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2019;23(83 ):17-24. Available from: https://sid.ir/paper/366679/en

IEEE: Copy

FATEH RAHIMI, and Mina Torabi, “Resistance to Aminoglycosides among Methicillin Resistant Staphylococcus aureus Strains Isolated from Patients with Urinary Tract Infection in Isfahan, Iran 2017,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 23, no. 83 , pp. 17–24, 2019, [Online]. Available: https://sid.ir/paper/366679/en

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