NEW APPROACH FOR THE SYNTHESIS, ENTRAPMENT OF HYDROPHILIC DRUGS AND EVALUATION OF PHYSICO- CHEMICAL CHARACTERISTICS OF PH- SENSITIVE NANO-LIPOSOME: IMPROVING THERAPEUTIC EFFICACY OF DOXORUBICIN IN ORDER TO TREATMENT BONE TUMOR AND REDUCING THE SIDE EFFECTS OF DOXORUBICIN

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Haghiralsadat Fatemeh; AMOABEDINY GHASEM; SHEIKHHA MOHAMMAD HASAN; MOHAMMAD NEZHAD MOHAMMAD JAVAD; NADERINEZHAD SAMIRA; MALAEI BALASI ZAHRA; ZANDIEH DOULABI BEHROUZ

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:24 | Issue:10 Page(s): 780-789

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Title

NEW APPROACH FOR THE SYNTHESIS, ENTRAPMENT OF HYDROPHILIC DRUGS AND EVALUATION OF PHYSICO- CHEMICAL CHARACTERISTICS OF PH- SENSITIVE NANO-LIPOSOME: IMPROVING THERAPEUTIC EFFICACY OF DOXORUBICIN IN ORDER TO TREATMENT BONE TUMOR AND REDUCING THE SIDE EFFECTS OF DOXORUBICIN

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Keywords

CANCERQ2

OSTEOSARCOMAQ2

CHARACTERIZATIONQ1

DOXORUBICINQ1

NANOQ1

LIPOSOMESQ1

PH_SENSITIVEQ1

Abstract

Introduction: CANCER is one of the most harmful disease throughout the world. DOXORUBICIN is an anti- CANCER agent, used in the treatment of various types of the CANCER such as bone CANCER. There are several adverse effects related to clinical usage of DOXORUBICIN for long time. The present study aimed to investigate the reducing side effects and enhancing the therapeutic effect by liposomal carrierMethods: LIPOSOMES containing DPPG and cholesterol with the molar ratio of 70:30 with the DOXORUBICIN were synthesized by pH- gradient method. The average diameter of NANOparticles and surface charge was determined by Zeta-Sizer instrument. The amount of drug loaded and drug-released was determined using dialysis. The surface morphology and internal lamella was evaluated by TEM and SEM.Results: The average size of liposomal DOXORUBICIN obtained using Zeta- Sizer was 126 nm. The encapsulation efficacy of liposomal DOXORUBICIN was 89%. The total amount of drug release during 48 hours in acidic medium studied by dialysis technique was 46%.Conclusion: In this study, investigation of loading DOXORUBICIN into NANO- liposome with the slow- released kinetic was carried out to improve the solubility and bioavailability of DOXORUBICIN in order to delivery to OSTEOSARCOMA cell line.

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APA: Copy

Haghiralsadat, Fatemeh, AMOABEDINY, GHASEM, SHEIKHHA, MOHAMMAD HASAN, MOHAMMAD NEZHAD, MOHAMMAD JAVAD, NADERINEZHAD, SAMIRA, MALAEI BALASI, ZAHRA, & ZANDIEH DOULABI, BEHROUZ. (2017). NEW APPROACH FOR THE SYNTHESIS, ENTRAPMENT OF HYDROPHILIC DRUGS AND EVALUATION OF PHYSICO- CHEMICAL CHARACTERISTICS OF PH- SENSITIVE NANO-LIPOSOME: IMPROVING THERAPEUTIC EFFICACY OF DOXORUBICIN IN ORDER TO TREATMENT BONE TUMOR AND REDUCING THE SIDE EFFECTS OF DOXORUBICIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(10), 780-789. SID. https://sid.ir/paper/36688/en

Vancouver: Copy

Haghiralsadat Fatemeh, AMOABEDINY GHASEM, SHEIKHHA MOHAMMAD HASAN, MOHAMMAD NEZHAD MOHAMMAD JAVAD, NADERINEZHAD SAMIRA, MALAEI BALASI ZAHRA, ZANDIEH DOULABI BEHROUZ. NEW APPROACH FOR THE SYNTHESIS, ENTRAPMENT OF HYDROPHILIC DRUGS AND EVALUATION OF PHYSICO- CHEMICAL CHARACTERISTICS OF PH- SENSITIVE NANO-LIPOSOME: IMPROVING THERAPEUTIC EFFICACY OF DOXORUBICIN IN ORDER TO TREATMENT BONE TUMOR AND REDUCING THE SIDE EFFECTS OF DOXORUBICIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;24(10):780-789. Available from: https://sid.ir/paper/36688/en

IEEE: Copy

Fatemeh Haghiralsadat, GHASEM AMOABEDINY, MOHAMMAD HASAN SHEIKHHA, MOHAMMAD JAVAD MOHAMMAD NEZHAD, SAMIRA NADERINEZHAD, ZAHRA MALAEI BALASI, and BEHROUZ ZANDIEH DOULABI, “NEW APPROACH FOR THE SYNTHESIS, ENTRAPMENT OF HYDROPHILIC DRUGS AND EVALUATION OF PHYSICO- CHEMICAL CHARACTERISTICS OF PH- SENSITIVE NANO-LIPOSOME: IMPROVING THERAPEUTIC EFFICACY OF DOXORUBICIN IN ORDER TO TREATMENT BONE TUMOR AND REDUCING THE SIDE EFFECTS OF DOXORUBICIN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 10, pp. 780–789, 2017, [Online]. Available: https://sid.ir/paper/36688/en

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