LONG TERM RESULTS OF BILATERAL ADRENALECTOMY FOR CUSHINGS DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAHRAMI A.; ABED MOGHADDAM A.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2004 | Volume:6 | Issue:3(SN 23) Page(s): 0-0

Download Full-Text

Persian Verion

View:

1,304

Download:

Cites:

Information Journal Paper

Title

LONG TERM RESULTS OF BILATERAL ADRENALECTOMY FOR CUSHINGS DISEASE

Author(s)

BAHRAMI A. | ABED MOGHADDAM A.R. | Issue Writer Certificate

Keywords

CUSHINGS DISEASEQ4

TOTAL ADRENALECTOMYQ4

NELSONS SYNDROMEQ4

Abstract

Introduction: Various investigations of total (bilateral) adrenalectomy for CUSHINGS DISEASE have yielded different results. Previous studies showed a different incidence and prognosis of NELSONS SYNDROME. The aim of this study is to investigate and present the long term results of TOTAL ADRENALECTOMY for bilateral adrenocortical hyperplasia (CUSHINGS DISEASE). Materials and Methods: During a ten-year period between 1991-2001, a total of 54 patients with Cushings syndrome were diagnosed and operated upon at teaching hospitals of Tabriz University of Medical Sciences and followed at endocrine clinics. Thirty-nine patients (27 females and 12 males) with CUSHINGS DISEASE and a mean age of 32. 6 years, underwent TOTAL ADRENALECTOMY and were followed for one to ten years (mean duration of follow up 6. 4 years). Results: The remission rate following bilateral adrenalectomy was 100%. In 2 patients after a period of steroid replacement therapy, there were signs of steroid overdosage. Replacement therapy was discontinued in both. Classic NELSONS SYNDROME characterized by severe and progressive mucocutaneous hyperpigmentation, very high levels of plasma ACTH and invasive macroadenoma as diagnosed by pituitary CT or MRI scan developed in 2 patients (5%) 4 and 6 years after adrenalectomy. In another 2 patients (5%), despite severe hyperpigmentation and very high levels of serum ACTH, there was no pituitary mass at imaging (non-classical NELSONS SYNDROME). Thus a total of 4 patients (10.2%) with a mean age of 23 years developed NELSONS SYNDROME during the follow up period. All patients were females. Three patients (two females and one male) died of colonic carcinoma, pancreatic malignancy, and metastatic adenocarcinoma of unknown origin with intraperitoneal seeding and liver metastasis. Conclusion: We conclude that TOTAL ADRENALECTOMY is an effective method of correction of hypercortisolism in CUSHINGS DISEASE. The incidence rate of NELSONS SYNDROME following TOTAL ADRENALECTOMY in the present study is lower than that reported in previous studies. It seems that younger females are at a higher risk of developing NELSONS SYNDROME.

Cites

No record.

References

No record.

Cite

APA: Copy

BAHRAMI, A., & ABED MOGHADDAM, A.R.. (2004). LONG TERM RESULTS OF BILATERAL ADRENALECTOMY FOR CUSHINGS DISEASE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 6(3(SN 23)), 0-0. SID. https://sid.ir/paper/366992/en

Vancouver: Copy

BAHRAMI A., ABED MOGHADDAM A.R.. LONG TERM RESULTS OF BILATERAL ADRENALECTOMY FOR CUSHINGS DISEASE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2004;6(3(SN 23)):0-0. Available from: https://sid.ir/paper/366992/en

IEEE: Copy

A. BAHRAMI, and A.R. ABED MOGHADDAM, “LONG TERM RESULTS OF BILATERAL ADRENALECTOMY FOR CUSHINGS DISEASE,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 6, no. 3(SN 23), pp. 0–0, 2004, [Online]. Available: https://sid.ir/paper/366992/en

Related Journal Papers