COMPARISON OF THE EFFICIENCY OF LOVASTATIN AND SEED DILL EXTRACT IN REDUCTION OF SERUM LIPID LEVELS IN RATS

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RAFATI A.; YAGHMAEI PARICHEHR; MORADI SIMA; ESMAILI DAHAJ M.; JALALI B.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2006 | Volume:13 | Issue:5 Page(s): 41-49

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Title

COMPARISON OF THE EFFICIENCY OF LOVASTATIN AND SEED DILL EXTRACT IN REDUCTION OF SERUM LIPID LEVELS IN RATS

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LOVASTATINQ4

SEED DILL EXTRACTQ3

ATHEROSCLEROSISQ4

SERUM LIPIDQ4

Abstract

Introduction: SERUM LIPID disorders are one of the important risk factors for development of coronary arterial ATHEROSCLEROSIS. The aim of this study was to compare the effects of the drug LOVASTATIN and a liquid vegetable extract (dill) on blood plasma lipid levels of rats.Methods: In this experimental study, 32 mouse vistar rats weighing 250±30 grams were included and maintained at 23±1 degrees Celsius. The rats were divided into 4 groups of 8 rats each. Groups I and II were given normal and high cholesterol diet, while groups III and IV were given high cholesterol diet with either LOVASTATIN or SEED DILL EXTRACT for a period of 3 weeks, respectively. At the end of study, blood samples were taken and plasma lipid levels determined by the manual method. (It is worth mentioning that ultimately 26 rats were included in the study groups).Results: Results showed that both administration of LOVASTATIN and the SEED DILL EXTRACT led to a significant reduction in plasma levels of cholesterol, triglycerides, LDL and LDL/HDL, TG/HDL ratios. There was a significant reduction in the levels of LDL (P<0.001) and also a significant increase in levels of HDL (P<0.001) in both the groups. The effects on plasma triglycerides levels, LDL/HDL and TG/HDL ratios were not significant.Conclusion: Considering the results of the study, SEED DILL EXTRACT affects plasma lipid levels and is more effective in lowering plasma cholesterol and LDL levels as compared to LOVASTATIN.

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APA: Copy

RAFATI, A., YAGHMAEI, PARICHEHR, MORADI, SIMA, ESMAILI DAHAJ, M., & JALALI, B.. (2006). COMPARISON OF THE EFFICIENCY OF LOVASTATIN AND SEED DILL EXTRACT IN REDUCTION OF SERUM LIPID LEVELS IN RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 13(5), 41-49. SID. https://sid.ir/paper/36713/en

Vancouver: Copy

RAFATI A., YAGHMAEI PARICHEHR, MORADI SIMA, ESMAILI DAHAJ M., JALALI B.. COMPARISON OF THE EFFICIENCY OF LOVASTATIN AND SEED DILL EXTRACT IN REDUCTION OF SERUM LIPID LEVELS IN RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;13(5):41-49. Available from: https://sid.ir/paper/36713/en

IEEE: Copy

A. RAFATI, PARICHEHR YAGHMAEI, SIMA MORADI, M. ESMAILI DAHAJ, and B. JALALI, “COMPARISON OF THE EFFICIENCY OF LOVASTATIN AND SEED DILL EXTRACT IN REDUCTION OF SERUM LIPID LEVELS IN RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 5, pp. 41–49, 2006, [Online]. Available: https://sid.ir/paper/36713/en

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