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Information Journal Paper

Title

The Effect of Maternal Aerobic Training Before and During Pregnancy on Vascular Tissue BAX/BCL-2 and eNOS Gene Expression in Adult Male Sprague Dawley Rats Offsprings

Pages

  417-434

Abstract

 Background and Objectives: It is also known that diseases may start in the utero stage of development. Pregnancy is an important part of women's life. Various aspects including physical activity can affect different indicators of child health in adulthood. One of the common and growing diseases is vascular disease, that eNOS, BCL-2 and BAX are related indices. The aim of this study was to investigate the effect of aerobic exercise before and during Pregnancy in adult males offsprings of Sprague Dawley rats on the expression of eNOS, BCL-2 and BAX genes in their femoral artery tissues. Materials and Methods: Twenty female Sprague Dawley rats (221 ± 10. 85g weight) were randomly divided into four groups: 1-exercise during Pregnancy (TP), 2-exercise before and during Pregnancy(Tbp), 3-exercise before Pregnancy (Tb), 4-no exercise control (C). Mice performed moderate-intensity aerobic exercise before and during Pregnancy. Tissue from the femoral artery of 8-week-old offspring rats was used to evaluate eNOS, BCL-2, BAX and BAX / BCL-2 gene expression. Results: Aerobic Training before and during Pregnancy, especially at both stages, resulted in a significant increase in eNOS and BCL-2 gene expression and a significant decrease in BAX and BAX/ BCL-2 gene expression. Conclusion: Based on these results, the present study showed that moderate-intensity aerobic exercise can make positive changes in factors related to vascular congestion in male offspring rats in which their mothers performed moderate-intensity aerobic exercises before and during their Pregnancy.

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    APA: Copy

    ABDOLLAHPOUR, AZAM, & ZARBAF, REYHANEH. (2019). The Effect of Maternal Aerobic Training Before and During Pregnancy on Vascular Tissue BAX/BCL-2 and eNOS Gene Expression in Adult Male Sprague Dawley Rats Offsprings. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(5 ), 417-434. SID. https://sid.ir/paper/367215/en

    Vancouver: Copy

    ABDOLLAHPOUR AZAM, ZARBAF REYHANEH. The Effect of Maternal Aerobic Training Before and During Pregnancy on Vascular Tissue BAX/BCL-2 and eNOS Gene Expression in Adult Male Sprague Dawley Rats Offsprings. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(5 ):417-434. Available from: https://sid.ir/paper/367215/en

    IEEE: Copy

    AZAM ABDOLLAHPOUR, and REYHANEH ZARBAF, “The Effect of Maternal Aerobic Training Before and During Pregnancy on Vascular Tissue BAX/BCL-2 and eNOS Gene Expression in Adult Male Sprague Dawley Rats Offsprings,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 5 , pp. 417–434, 2019, [Online]. Available: https://sid.ir/paper/367215/en

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