Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion

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Mazdapour Manouchehr; DehghaniAshkezari Mahmood; Seifati SeyedMorteza

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:27 | Issue:2 Page(s): 1254-1261

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Title

Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion

Author(s)

Mazdapour Manouchehr | DehghaniAshkezari Mahmood | Seifati SeyedMorteza | Issue Writer Certificate

Keywords

Recurrent spontaneous abortionQ2

InfertilityQ2

PolymorphismQ2

HOXA10Q1

Abstract

Introduction: Recurrent spontaneous abortion is defined as the occurrence of more than two clinical miscarriages in one woman. Several factors, including endocrine irregularities, genetics and environmental factors, are involved in this kind of Infertility. The aim of this study was to survey the association of HOXA10 (rs267601473) Polymorphism with the risk of Recurrent spontaneous abortion in our population. Methods: In the present case-control study, the HOXA10 (rs267601473) Polymorphism was investigated in 70 infertile woman and 100 healthy participants using PCR-RFLP methods. Then, the data were analyzed by SPSS software version 18 and also were compared using Chi-square test and Logistic regression model. The p-value was found to be statistically significant (p<0. 05). Results: Our results showed significant association between the HOXA10 (rs267601473) Polymorphism and Recurrent spontaneous abortion (OR=0. 143, 95% CI=0. 056-0. 368; p<0. 0001). Our findings showed that T allele frequency in women with Recurrent spontaneous abortion had significant difference compared to the control group (OR=0. 2, 95% CI=0. 11-0. 4; p<0. 0001). Conclusion: The results of this study reveal that the HOXA10 (rs267601473) Polymorphism is significantly associated with Recurrent spontaneous abortion in our population.

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References

Decreased experession of HOXA10 may activate the autophagic process in ovarian endometriosis

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APA: Copy

Mazdapour, Manouchehr, DehghaniAshkezari, Mahmood, & Seifati, SeyedMorteza. (2019). Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(2 ), 1254-1261. SID. https://sid.ir/paper/36723/en

Vancouver: Copy

Mazdapour Manouchehr, DehghaniAshkezari Mahmood, Seifati SeyedMorteza. Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(2 ):1254-1261. Available from: https://sid.ir/paper/36723/en

IEEE: Copy

Manouchehr Mazdapour, Mahmood DehghaniAshkezari, and SeyedMorteza Seifati, “Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 2 , pp. 1254–1261, 2019, [Online]. Available: https://sid.ir/paper/36723/en

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