Design of an Inhalation Chamber to Expose Laboratory Animals with Suspended Particulate Matter Using Numerical Simulation Method

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RAJABI VARDANJANI HASSAN; ASILIAN MAHABADI HASSAN; Bayareh Morteza; SEDEHI MORTEZA

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Journal: Journal of Health and Safety at Work Year:2020 | Volume:9 | Issue:4 Page(s): 346-358

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Title

Design of an Inhalation Chamber to Expose Laboratory Animals with Suspended Particulate Matter Using Numerical Simulation Method

Author(s)

RAJABI VARDANJANI HASSAN | ASILIAN MAHABADI HASSAN | Bayareh Morteza | SEDEHI MORTEZA | Issue Writer Certificate

Keywords

Exposure chamberQ1

Numerical simulationQ1

Particulate mattersQ1

Inhalation exposureQ1

Abstract

Introduction: In toxicological studies of particulate matter (PM), inhalation Exposure chambers (IEC) are usually used for distributing the test atmosphere uniformly and stability in the respiratory zone of laboratory animals. This study was aimed to design, evaluate and optimize a whole-body IEC, to expose small laboratory animals with PM. Material and Methods: The initial design of the chamber was determined based on the advantages and disadvantages of the existing chambers. To create a uniform distribution of particles, metal guide plates were used in the upper cone. ANSYS Fluent software was used for Numerical simulation and optimize the initial design. The used particles had a mean aerodynamic diameter of 10 microns. Particle concentration was measured along the cylindrical radius at 10 cm intervals on the x-axis. Then the percentage of variation coefficient (CV%) of the particle concentration for each line was calculated. The design with the lowest CV% was selected as the best chamber design. Results: The optimized design has a cylinder section with two upper and lower cones, and two guide plates and its CV equal to 4. 08%. Conclusion: The optimized design was provided with a uniform and stable distribution of the particles to expose small laboratory animals.

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APA: Copy

RAJABI VARDANJANI, HASSAN, ASILIAN MAHABADI, HASSAN, Bayareh, Morteza, & SEDEHI, MORTEZA. (2020). Design of an Inhalation Chamber to Expose Laboratory Animals with Suspended Particulate Matter Using Numerical Simulation Method. JOURNAL OF HEALTH AND SAFETY AT WORK, 9(4), 346-358. SID. https://sid.ir/paper/367578/en

Vancouver: Copy

RAJABI VARDANJANI HASSAN, ASILIAN MAHABADI HASSAN, Bayareh Morteza, SEDEHI MORTEZA. Design of an Inhalation Chamber to Expose Laboratory Animals with Suspended Particulate Matter Using Numerical Simulation Method. JOURNAL OF HEALTH AND SAFETY AT WORK[Internet]. 2020;9(4):346-358. Available from: https://sid.ir/paper/367578/en

IEEE: Copy

HASSAN RAJABI VARDANJANI, HASSAN ASILIAN MAHABADI, Morteza Bayareh, and MORTEZA SEDEHI, “Design of an Inhalation Chamber to Expose Laboratory Animals with Suspended Particulate Matter Using Numerical Simulation Method,” JOURNAL OF HEALTH AND SAFETY AT WORK, vol. 9, no. 4, pp. 346–358, 2020, [Online]. Available: https://sid.ir/paper/367578/en

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