INTRANASAL AND SUBCUTANEOUS IMMUNIZATION TECHNIQUES FOR
ANTI-SPERM ANTIBODY INDUCTION AND DISRUPTION OF FERTILITY IN FEMALE
RABBITS

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TARAVATI M.R.; SANKIAN M.; SADEGH KHALILI FAHIMEH; SADAGHIANI M.

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Journal: Studies in Medical Sciences Year:2003 | Volume:14 | Issue:2 Page(s): 141-142

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Title

INTRANASAL AND SUBCUTANEOUS IMMUNIZATION TECHNIQUES FOR ANTI-SPERM ANTIBODY INDUCTION AND DISRUPTION OF FERTILITY IN FEMALE RABBITS

Author(s)

TARAVATI M.R. | SANKIAN M. | SADEGH KHALILI FAHIMEH | SADAGHIANI M. | Issue Writer Certificate

Keywords

INFERTILITYQ2

ANTISPERM ANTIBODYQ4

ELLSAQ3

Abstract

Background and Aim: Birth control is one of the major problem worldwide. So far many attempts have been made to disrupt reproductive function in both male and female. Numerous reports have implicated antisperm antibodies as one of the causative factors of INFERTILITY among women. The aim of this study was, evaluation of the route of immunization and assessment of the effect of anti sperm antibody in disruption of fertility among female rabbits. Materials & Methods: Sixteen female rabbits were chosen and divided into two groups. Sperm was prepared from male rabbits. First group was immunized intranasally and second group subcutaneously. Antisperm antibody level was detected in sera and cervical mucus by employing ELISA, SDS-PAGE and immunoblotting assays. Results: Two rabbits from first group were infertile. However, no INFERTILITY was observed in second group. The SDS-PAGE and immunoblotting pattern indicated that 46KD protein is a main antigen which stimulated immune system to produce antisperm a antbody. Discussion: The results revealed that inoculation of sperm antigen with intranasal route is the hest way for production of anti-sperm antibody in endocervical mucus. The SDS-PAGE patterns indicated 46 KD protein is the main antigen. Most probably by purification of this protein from spermatozoa and inoculation to animal ANTISPERM ANTIBODY impair fertility. More evaluation is necessary.

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APA: Copy

TARAVATI, M.R., SANKIAN, M., SADEGH KHALILI, FAHIMEH, & SADAGHIANI, M.. (2003). INTRANASAL AND SUBCUTANEOUS IMMUNIZATION TECHNIQUES FOR ANTI-SPERM ANTIBODY INDUCTION AND DISRUPTION OF FERTILITY IN FEMALE RABBITS . STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 14(2), 141-142. SID. https://sid.ir/paper/368153/en

Vancouver: Copy

TARAVATI M.R., SANKIAN M., SADEGH KHALILI FAHIMEH, SADAGHIANI M.. INTRANASAL AND SUBCUTANEOUS IMMUNIZATION TECHNIQUES FOR ANTI-SPERM ANTIBODY INDUCTION AND DISRUPTION OF FERTILITY IN FEMALE RABBITS . STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2003;14(2):141-142. Available from: https://sid.ir/paper/368153/en

IEEE: Copy

M.R. TARAVATI, M. SANKIAN, FAHIMEH SADEGH KHALILI, and M. SADAGHIANI, “INTRANASAL AND SUBCUTANEOUS IMMUNIZATION TECHNIQUES FOR ANTI-SPERM ANTIBODY INDUCTION AND DISRUPTION OF FERTILITY IN FEMALE RABBITS ,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 14, no. 2, pp. 141–142, 2003, [Online]. Available: https://sid.ir/paper/368153/en

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