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Information Journal Paper

Title

Evaluation of hydroalcoholic extract of Thyme on malondialdehyde, thiol, and glutathione peroxidase concentration in the Parkinson's model induced by 6-hydroxydopamine in adult male rats

Pages

  325-334

Abstract

 Background: Parkinson's disease (PD) is a neuropathologic disorder caused by dopaminergic neurons degeneration in the dense part of the substantia nigra. Objective: The present study, designed to evaluate the effect of hydroalcoholic extract of thyme on Malondialdehyde (MDA), Thiol, and Glutathione peroxidase (GPX) concentration in the PD induced by 6-hydroxydopamine in an animal model. Methods: In this experimental study, 40 male rats, were divided randomly into five groups (n=8) including control and PD group in which PD was induced by 4 μ g 6-hydroxydopamine neurotoxin in medial forebrain bundle (MFB). Treatment groups received 100, 200 and 400 mg/kg thyme extract via intragastric administration for 14 days and then, the brains of the rats were extracted to evaluate lipid peroxidation and measure the levels of Thiol (-SH) and GPX. Results: The significant increase in MDA concentration in the cerebral cortex, hippocampus, striatum (P< 0. 05) and cerebellum (P< 0. 001) and a significant reduction in Thiol and GPX enzyme (P< 0. 001) were reported in rats with PD. Treatment with thyme extract significantly increased Thiol and GPX (P< 0. 001) and significantly reduced MDA in the hippocampus, striatum (P< 0. 001) and cerebral cortex (P< 0. 01). Conclusion: Thyme extract showed potent antioxidant activity in an animal model of PD.

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    APA: Copy

    DOULAH, ABDOLHASSAN, RAFIEIRAD, MARYAM, & ZANGANEHNEJAD, ZAHRA. (2020). Evaluation of hydroalcoholic extract of Thyme on malondialdehyde, thiol, and glutathione peroxidase concentration in the Parkinson's model induced by 6-hydroxydopamine in adult male rats. JOURNAL OF MEDICINAL PLANTS, 19(74 ), 325-334. SID. https://sid.ir/paper/368361/en

    Vancouver: Copy

    DOULAH ABDOLHASSAN, RAFIEIRAD MARYAM, ZANGANEHNEJAD ZAHRA. Evaluation of hydroalcoholic extract of Thyme on malondialdehyde, thiol, and glutathione peroxidase concentration in the Parkinson's model induced by 6-hydroxydopamine in adult male rats. JOURNAL OF MEDICINAL PLANTS[Internet]. 2020;19(74 ):325-334. Available from: https://sid.ir/paper/368361/en

    IEEE: Copy

    ABDOLHASSAN DOULAH, MARYAM RAFIEIRAD, and ZAHRA ZANGANEHNEJAD, “Evaluation of hydroalcoholic extract of Thyme on malondialdehyde, thiol, and glutathione peroxidase concentration in the Parkinson's model induced by 6-hydroxydopamine in adult male rats,” JOURNAL OF MEDICINAL PLANTS, vol. 19, no. 74 , pp. 325–334, 2020, [Online]. Available: https://sid.ir/paper/368361/en

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