NEUROPROTECTIVE EFFECTS OF URIC ACID ON AXOTOMIZED SPINAL MOTONEURONS IN NEONATE RATS

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AZIZZADEH DELSHAD ALIREZA; JALALI NADOUSHAN MOHAMMAD REZA; GHAFOORIMEHR FATEMEH

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Journal: Koomesh Year:2016 | Volume:17 | Issue:3 (59) Page(s): 772-778

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Title

NEUROPROTECTIVE EFFECTS OF URIC ACID ON AXOTOMIZED SPINAL MOTONEURONS IN NEONATE RATS

Author(s)

AZIZZADEH DELSHAD ALIREZA | JALALI NADOUSHAN MOHAMMAD REZA | GHAFOORIMEHR FATEMEH | Issue Writer Certificate

Keywords

URIC ACIDQ2

NEUROPROTECTIONQ1

MOTONEURONQ2

APOPTOSISQ1

AXOTOMYQ3

NEONATE RATQ1

Abstract

Introduction: Recently the neuroprotective role of URIC ACID (UA), as a natural biochemical substance, in neurodegenerative diseases has been proposed. Due to the critical role of APOPTOSIS in many diseases of the nervous system, the present study was designed to investigate the anti-apoptotic effect of UA on motor neurons of the ventral spinal horn in NEONATE RATs.Materials and Methods: Two-day-old rat neonates (n=10) were subdivided into experimental and control groups. In both groups, right sciatic nerve was transected. Experimental neonates were immediately treated with 10mg/kg UA intraperitoneally, while the control’s wound was closed without treatment. Five days after AXOTOMY, transverse sections of spinal cord at L5 level were prepared for morphometric cell count and TUNNEL assay.Results: The motor neuron loss in axotomized side compared to intact side was 30.48%, which illustrates the effectiveness of AXOTOMY in inducing MOTONEURON cell death. The TUNNEL assay confirmed the apoptotic characteristics of cell death. Comparing the mean MOTONEURONs loss in the axotomized side of the control and UA-treated neonates, revealed a significant difference between the two groups (p<0.05). Also in both control and experimental groups, the difference between the apoptotic Index of the axotomized and intact sides was statistically significant (p<0.05).Conclusion: Neuroprotective effect of UA is possibly through inhibiting the apoptotic cell death, which occurred with the axotomized MOTONEURONs in ventral spinal horn.

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APA: Copy

AZIZZADEH DELSHAD, ALIREZA, JALALI NADOUSHAN, MOHAMMAD REZA, & GHAFOORIMEHR, FATEMEH. (2016). NEUROPROTECTIVE EFFECTS OF URIC ACID ON AXOTOMIZED SPINAL MOTONEURONS IN NEONATE RATS. KOOMESH, 17(3 (59)), 772-778. SID. https://sid.ir/paper/36876/en

Vancouver: Copy

AZIZZADEH DELSHAD ALIREZA, JALALI NADOUSHAN MOHAMMAD REZA, GHAFOORIMEHR FATEMEH. NEUROPROTECTIVE EFFECTS OF URIC ACID ON AXOTOMIZED SPINAL MOTONEURONS IN NEONATE RATS. KOOMESH[Internet]. 2016;17(3 (59)):772-778. Available from: https://sid.ir/paper/36876/en

IEEE: Copy

ALIREZA AZIZZADEH DELSHAD, MOHAMMAD REZA JALALI NADOUSHAN, and FATEMEH GHAFOORIMEHR, “NEUROPROTECTIVE EFFECTS OF URIC ACID ON AXOTOMIZED SPINAL MOTONEURONS IN NEONATE RATS,” KOOMESH, vol. 17, no. 3 (59), pp. 772–778, 2016, [Online]. Available: https://sid.ir/paper/36876/en

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