Effect of 6 Weeks Aerobic Training on Peripheral Neuropathic Pain and its Effect on Expression of Notch-1 Receptor and JAK/STAT Signaling Pathway in Posterior Spinal Cord of Diabetic Male Rats

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Hosseini Askarabadi Siros; MIRNASOURI RAHIM; RAHMATI MASOUD

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Journal: Jundishapur Scientific Medical Journal Year:2019 | Volume:18 | Issue:1 Page(s): 95-107

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Title

Effect of 6 Weeks Aerobic Training on Peripheral Neuropathic Pain and its Effect on Expression of Notch-1 Receptor and JAK/STAT Signaling Pathway in Posterior Spinal Cord of Diabetic Male Rats

Author(s)

Hosseini Askarabadi Siros | MIRNASOURI RAHIM | RAHMATI MASOUD | Issue Writer Certificate

Keywords

Aerobic exerciseQ1

Peripheral neuropathic painQ1

NOTCH1Q1

STAT3Q1

DiabetesQ2

Abstract

Background and Objective: The Peripheral neuropathic pain is one of the major and largely untreated pain for which physical activity is considered as the main stream treatment. The purpose of this experimental study was to evaluate the effect of 6 weeks aerobic training on Peripheral neuropathic pain and on the expression of the NOTCH1 receptor and to assess the role of JAK/STAT pathway in the spinal cord of diabetic male rats. Subjects and Methods: Forty male Wistar rats (age: 8 weeks old; weight 220± 10. 2g) were randomly divided into 4 groups: diabetic neuropathy training (DNT), diabetic neuropathy control (DNC), healthy training (HT) and healthy control (HC). The diabetic groups two weeks after induction of Diabetes, behavioral pain tests were administered and endurance training protocol was performed for 6 weeks at 5 sessions per week. To evaluate the expression of NOTCH1, IL6, TNF-a and STAT3 were measured using Real Time PCR technique. For analysis of the data, one-way ANOVA statistical test was used and significant level was considered at P <0. 05. Results: After 6 weeks of aerobic training, the expression of NOTCH1, IL6, TNF-aand STAT3 genes in diabetic neuropathy training group was significantly lower than the diabetic neuropathy control group. The mean weight of the diabetic neuropathic training group was more than the diabetic neuropathy control group. In addition, exercise significantly decreased blood glucose level in the diabetic neuropathy group. Conclusion: The results show that Aerobic exercise can effect pain sensation in rats with diabetic neuropathy. In addition, Aerobic exercise, seems to induce this action by reducing the level of expression of NOTCH1, IL6, TNF-a and STAT3.

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APA: Copy

Hosseini Askarabadi, Siros, MIRNASOURI, RAHIM, & RAHMATI, MASOUD. (2019). Effect of 6 Weeks Aerobic Training on Peripheral Neuropathic Pain and its Effect on Expression of Notch-1 Receptor and JAK/STAT Signaling Pathway in Posterior Spinal Cord of Diabetic Male Rats. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(1 ), 95-107. SID. https://sid.ir/paper/369036/en

Vancouver: Copy

Hosseini Askarabadi Siros, MIRNASOURI RAHIM, RAHMATI MASOUD. Effect of 6 Weeks Aerobic Training on Peripheral Neuropathic Pain and its Effect on Expression of Notch-1 Receptor and JAK/STAT Signaling Pathway in Posterior Spinal Cord of Diabetic Male Rats. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(1 ):95-107. Available from: https://sid.ir/paper/369036/en

IEEE: Copy

Siros Hosseini Askarabadi, RAHIM MIRNASOURI, and MASOUD RAHMATI, “Effect of 6 Weeks Aerobic Training on Peripheral Neuropathic Pain and its Effect on Expression of Notch-1 Receptor and JAK/STAT Signaling Pathway in Posterior Spinal Cord of Diabetic Male Rats,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 1 , pp. 95–107, 2019, [Online]. Available: https://sid.ir/paper/369036/en

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