The Effect of Six Weeks Aerobic Training on Serum and Hepatic Ascorbic Acid Levels and Hepatic SVCT2 Level in Diabetic Wistar Rats

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Boyerahmadi Amin; TADIBI VAHID; HOSSEINPOUR DELAVAR SEDIGHEH; BEHPOUR NASER

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Journal: Jundishapur Scientific Medical Journal Year:2019 | Volume:18 | Issue:3 Page(s): 253-261

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Title

The Effect of Six Weeks Aerobic Training on Serum and Hepatic Ascorbic Acid Levels and Hepatic SVCT2 Level in Diabetic Wistar Rats

Author(s)

Boyerahmadi Amin | TADIBI VAHID | HOSSEINPOUR DELAVAR SEDIGHEH | BEHPOUR NASER | Issue Writer Certificate

Keywords

DiabetesQ2

LiverQ2

Aerobic ExerciseQ1

Ascorbic AcidQ3

Sodium-dependent vitamin C transporter 2Q1

Abstract

Background an Objective: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in the transport of Ascorbic Acid into the cell. The purpose of this study was to investigate the effect of Diabetes induction and exercise training on hepatic Ascorbic Acid and SVCT2 levels in Wistar rats. Material and Methods: In this experimental study, 20 male Wistar rats were randomly divided into 4 groups: 1: healthy control), 2: Diabetes control, 3: Diabetes-exercise and 4: sham. After Diabetes induction training program consisted of 6 weeks of running on the treadmill, 5 sessions per week and each session of 20 to 40 minutes at a speed of 10-20 m/min was applied. Liver tissue and serum levels were used to investigate the effect of exercise training on Ascorbic Acid metabolism. Results: The results showed that induction of Diabetes significantly decreased serum and hepatic Ascorbic Acid levels in the diabetic and diabetic-exercise groups compared with the control and sham groups (P<0. 001). Also, hepatic SVCT2 was significantly increased in the diabetic group compared to the control group (P=0. 041) and significantly increased in the diabetic and diabetic-exercise groups compared to the sham group (P<0. 05). Conclusion: According to the results of this study, induction of Diabetes reduces hepatic Ascorbic Acid levels, this appears to be associated with a decrease in serum Ascorbic Acid levels, and increased levels of Liver SVCT2 are an up regulation mechanism to compensate for lower levels of Liver Ascorbic Acid. Aerobic training after induction of Diabetes, had no significant effect on the above mentioned variables.

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References

The Effect of Six Weeks Aerobic Training on Serum and Muscle Levels of Ascorbic Acid And SVCT2 of Soleus Muscle Tissue in Wistar Rats

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APA: Copy

Boyerahmadi, Amin, TADIBI, VAHID, HOSSEINPOUR DELAVAR, SEDIGHEH, & BEHPOUR, NASER. (2019). The Effect of Six Weeks Aerobic Training on Serum and Hepatic Ascorbic Acid Levels and Hepatic SVCT2 Level in Diabetic Wistar Rats. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(3 ), 253-261. SID. https://sid.ir/paper/369600/en

Vancouver: Copy

Boyerahmadi Amin, TADIBI VAHID, HOSSEINPOUR DELAVAR SEDIGHEH, BEHPOUR NASER. The Effect of Six Weeks Aerobic Training on Serum and Hepatic Ascorbic Acid Levels and Hepatic SVCT2 Level in Diabetic Wistar Rats. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(3 ):253-261. Available from: https://sid.ir/paper/369600/en

IEEE: Copy

Amin Boyerahmadi, VAHID TADIBI, SEDIGHEH HOSSEINPOUR DELAVAR, and NASER BEHPOUR, “The Effect of Six Weeks Aerobic Training on Serum and Hepatic Ascorbic Acid Levels and Hepatic SVCT2 Level in Diabetic Wistar Rats,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 3 , pp. 253–261, 2019, [Online]. Available: https://sid.ir/paper/369600/en

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