COMPARISON OF LOW VOLTAGE AMPLITUDE ELECTROCHEMOTHERAPY WITH 1 HZ AND 5 KHZ FREQUENCY IN VOLUME REDUCTION OF MOUSE MAMMARY TUMOR IN BALB/C MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHANKAYI ZEINAB; FIROOZABADI SEYED MOHAMMD; SARRAF HASSAN ZAHIR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2012 | Volume:13 | Issue:4 (44) Page(s): 486-490

Download Full-Text

Persian Verion

View:

1,113

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF LOW VOLTAGE AMPLITUDE ELECTROCHEMOTHERAPY WITH 1 HZ AND 5 KHZ FREQUENCY IN VOLUME REDUCTION OF MOUSE MAMMARY TUMOR IN BALB/C MICE

Author(s)

SHANKAYI ZEINAB | FIROOZABADI SEYED MOHAMMD | SARRAF HASSAN ZAHIR | Issue Writer Certificate

Keywords

ELECTROPORATIONQ2

ELECTROCHEMOTHERAPYQ2

PULSE FREQUENCYQ2

PULSE AMPLITUDEQ2

BREAST NEOPLASMSQ2

MICEQ2

INBRED BALB CQ2

Abstract

Introduction: ELECTROCHEMOTHERAPY (ECT) is an efficient technique that high intensity electric pulses in combination with chemotherapeutic drugs are applied to tumor cells. The most important unpleasant sensation of ELECTROCHEMOTHERAPY is muscle contraction. To resolve this problem, there are two solutions: first, increasing the repetition frequency of electric pulses above the tetanic frequency; and, second, reducing the voltage amplitude. ECT using 1 Hz or 5 kHz frequency at high amplitude examined and no difference response of the tumor treatment was observed. But the role of frequency in low amplitude ECT not examined. Therefore, the present study compared the anti-tumor effectiveness of ELECTROCHEMOTHERAPYusing electric pulses with frequencies of 1 Hz and 5 kHz at 70 v/cm amplitude.Materials and Methods: ECT of spontaneous mouse mammary tumor (SMMT) transplanted in Balb/c was performed with intratumoral injection of bleomycine and applied four different electric pulse protocols: 1- a train of 8 pulses with duration 50 ms, 1 Hz frequency and 70 v/cm amplitude, 2- a train of 4000 pulses with duration 100 ms, 5k Hz frequency and 70 v/cm amplitude, 3- a train of 8 pulses with duration 100 ms, 1 Hz frequency and 1000 v/cm amplitude, 4- a train of 8 pulses with duration 100 ms, 5 kHz frequency and 1000 v/cm amplitude.Results: Our data demonstrate significant differences in tumor volumes between MICE treated by 70 V/cm and 5 kHz frequencycompared to1 Hz frequency but inhibited tumor growth in high amplitude with 1 Hz and 5 kHz is comparable. Based on these results, the pulses with 70 v/cm and 5 kHz frequency are most effective.Conclusion: On the basis of these results the frequency effect of electric pulses is important in low amplitude ECT.

Cites

No record.

References

No record.

Cite

APA: Copy

SHANKAYI, ZEINAB, FIROOZABADI, SEYED MOHAMMD, & SARRAF HASSAN, ZAHIR. (2012). COMPARISON OF LOW VOLTAGE AMPLITUDE ELECTROCHEMOTHERAPY WITH 1 HZ AND 5 KHZ FREQUENCY IN VOLUME REDUCTION OF MOUSE MAMMARY TUMOR IN BALB/C MICE. KOOMESH, 13(4 (44)), 486-490. SID. https://sid.ir/paper/36963/en

Vancouver: Copy

SHANKAYI ZEINAB, FIROOZABADI SEYED MOHAMMD, SARRAF HASSAN ZAHIR. COMPARISON OF LOW VOLTAGE AMPLITUDE ELECTROCHEMOTHERAPY WITH 1 HZ AND 5 KHZ FREQUENCY IN VOLUME REDUCTION OF MOUSE MAMMARY TUMOR IN BALB/C MICE. KOOMESH[Internet]. 2012;13(4 (44)):486-490. Available from: https://sid.ir/paper/36963/en

IEEE: Copy

ZEINAB SHANKAYI, SEYED MOHAMMD FIROOZABADI, and ZAHIR SARRAF HASSAN, “COMPARISON OF LOW VOLTAGE AMPLITUDE ELECTROCHEMOTHERAPY WITH 1 HZ AND 5 KHZ FREQUENCY IN VOLUME REDUCTION OF MOUSE MAMMARY TUMOR IN BALB/C MICE,” KOOMESH, vol. 13, no. 4 (44), pp. 486–490, 2012, [Online]. Available: https://sid.ir/paper/36963/en

Related Journal Papers