Comparison of Effects of High-Fat, High-Protein and Low-Calorie Diets on Klotho Gene Expression and TGF-β Level in Serum and Liver of Old Male Wistar Rats

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RAHIMI A.M.; SHAFIEE A.; NABAVIZADEH F.; Ashabi gh.

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Journal: JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY Year:2020 | Volume:15 | Issue:3 Page(s): 1-8

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Title

Comparison of Effects of High-Fat, High-Protein and Low-Calorie Diets on Klotho Gene Expression and TGF-β Level in Serum and Liver of Old Male Wistar Rats

Author(s)

RAHIMI A.M. | SHAFIEE A. | NABAVIZADEH F. | Ashabi gh. | Issue Writer Certificate

Keywords

Aging;KlothoQ1

TGF-βQ1

High-protein dietQ1

High-fat dietQ1

Low-calorie dietQ1

Abstract

Background and Objectives: Different diets have important roles in human health and aging. In the current study, we aimed to characterize the Klotho, an anti-aging protein, gene expression and protein level in the serum and assess the protein levels of Transforming growth factor-β and Platelet-derived growth factor in old rats which treated with different diets (high-fat, high-protein, low calorie, high-protein and low calorie). Materials & Methods: Twenty-five old and five adult rats were treated with high-fat, high-protein, low calorie, high-protein and Low-calorie diets for ten weeks. Then, serum protein levels of Klotho, transforming growth factor-β and platelet-derived growth factor and gene expression of Klotho in the liver were assessed using enzyme-linked immunosorbent assay. Results: Protein level of Klotho in the blood serum and expression level of Klotho gene in the liver wer e increased in high-protein, low-calorie and low-calorie High-protein diets in comparison to control old group (p = 0. 000). The levels of transforming growth factor-β and platelet-derived growth factor were increased in low-calorie high-protein group, compared to old group in the liver (p = 0. 000). Conclusion: Results revealed that expression of Klotho decreased in old rats while low-calorie high-protein and particularly low-calorie High-protein diets increased this protein. Moreover, these protective diets could enhance transforming growth factor-β and platelet-derived growth factor in liver of rats, veryfieing improvement of the liver function.

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APA: Copy

RAHIMI, A.M., SHAFIEE, A., NABAVIZADEH, F., & Ashabi, gh.. (2020). Comparison of Effects of High-Fat, High-Protein and Low-Calorie Diets on Klotho Gene Expression and TGF-β Level in Serum and Liver of Old Male Wistar Rats. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 15(3 ), 1-8. SID. https://sid.ir/paper/370638/en

Vancouver: Copy

RAHIMI A.M., SHAFIEE A., NABAVIZADEH F., Ashabi gh.. Comparison of Effects of High-Fat, High-Protein and Low-Calorie Diets on Klotho Gene Expression and TGF-β Level in Serum and Liver of Old Male Wistar Rats. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2020;15(3 ):1-8. Available from: https://sid.ir/paper/370638/en

IEEE: Copy

A.M. RAHIMI, A. SHAFIEE, F. NABAVIZADEH, and gh. Ashabi, “Comparison of Effects of High-Fat, High-Protein and Low-Calorie Diets on Klotho Gene Expression and TGF-β Level in Serum and Liver of Old Male Wistar Rats,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 15, no. 3 , pp. 1–8, 2020, [Online]. Available: https://sid.ir/paper/370638/en

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