Effect of Mesenchymal Stem Cell Conditioned Medium on Proliferation of A549 and JEG3 Cancer Cell Lines

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HOSSEINZADEH SHAHNAZ; RANJBARAN HOSSEIN; ABEDIANKENARI SAEID

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Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:30 | Issue:187 Page(s): 49-57

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Title

Effect of Mesenchymal Stem Cell Conditioned Medium on Proliferation of A549 and JEG3 Cancer Cell Lines

Author(s)

HOSSEINZADEH SHAHNAZ | RANJBARAN HOSSEIN | ABEDIANKENARI SAEID | Issue Writer Certificate

Keywords

conditioned mediumQ1

msenchymal stem cellQ1

A549 cell lineQ1

JEG3 cell lineQ1

MTT assayQ2

Abstract

Background and purpose: Cancer is a serious public health problem. Some studies indicated the anti-cancer effects of mesenchymal stem cells (MSCs) associated with stem cells or their secretory mediators. The aim of this study was to evaluate the impact of conditioned medium derived from MSCs on A549 and JEG3 cancer cell lines. Materials and methods: In an experimental study, A549 and JEG3 cell lines were provided and grown in the culture media of DMEM F12 containing 10% fetal bovine serum. They were then treated with different percentages of conditioned medium from mesenchymal stem cells (5, 10, 20, 40, 50, and 100) for 48 hours. Metabolic activity was evaluated by MTT assay. Results: MTT assay showed that various percentages of condition medium from mesenchymal stem cells had inhibitory effects on A549 cell line and significant differences were observed between treated cells and control cells (P< 0. 05). Conclusion: Current study showed different effects of conditioned medium from mesenchymal stem cells, including suppressive effect on A549 cell line. Therefore, MSCs and their secretory paracrine factors could be considered as one of the treatment purposes in this cancer.

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APA: Copy

HOSSEINZADEH, SHAHNAZ, RANJBARAN, HOSSEIN, & ABEDIANKENARI, SAEID. (2020). Effect of Mesenchymal Stem Cell Conditioned Medium on Proliferation of A549 and JEG3 Cancer Cell Lines. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(187 ), 49-57. SID. https://sid.ir/paper/371001/en

Vancouver: Copy

HOSSEINZADEH SHAHNAZ, RANJBARAN HOSSEIN, ABEDIANKENARI SAEID. Effect of Mesenchymal Stem Cell Conditioned Medium on Proliferation of A549 and JEG3 Cancer Cell Lines. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(187 ):49-57. Available from: https://sid.ir/paper/371001/en

IEEE: Copy

SHAHNAZ HOSSEINZADEH, HOSSEIN RANJBARAN, and SAEID ABEDIANKENARI, “Effect of Mesenchymal Stem Cell Conditioned Medium on Proliferation of A549 and JEG3 Cancer Cell Lines,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 187 , pp. 49–57, 2020, [Online]. Available: https://sid.ir/paper/371001/en

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