Effect of citric acid on p53 and p21 genes expression of the human colorectal Adenocarcinoma cell line

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Mojodi Alireza; ROUHI LEILA; Khashei Varnamkhasti Khalil

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Journal: JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES Year:2021 | Volume:8 | Issue:4 Page(s): 1-9

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Title

Effect of citric acid on p53 and p21 genes expression of the human colorectal Adenocarcinoma cell line

Author(s)

Mojodi Alireza | ROUHI LEILA | Khashei Varnamkhasti Khalil | Issue Writer Certificate

Keywords

Citric AcidQ1

Colorectal adenocarcinomaQ1

Gene ExpressionQ1

p53geneQ1

p21geneQ1

Abstract

Background & Aim: Despite the advances in treatment of Colorectal adenocarcinoma patients continue to have low survival. Citric Acid is considered as a physiological inhibitor of enzymes involved in glycolysis pathway to remove cancer cells. The p53 and p21 gene products are involved in cell removal due to their pro-apoptotic properties. In this study, the effect of Citric Acid on p53 and p21 genes expression of the human Colorectal adenocarcinoma cell line (HT29) examined. Methods: In this study, HT-29 cells were treated by different concentrations of Citric Acid (400, 800 and 1600 μ g/ml) and the expression of P53 and p21 genes were examined after 24 and 48 hours. And results were analyzed by Real Time PCR. Statistical analysis was accomplished by ANOVA tests using SPSS 18 software. Results: According to results, treatment with Citric Acid increased the expression of p21 (P=. 044) and p53 (P=. 036) genes in some experimental groups (800 and 1600 μ g/ml for p53gen and 1600 μ g/ml for p21gene) compared to the control group. Conclusion: Citric Acid seems to be useful as an anticancer agent for the treatment of Colorectal adenocarcinoma by inducing expression of genes that involved in the apoptosis pathway.

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APA: Copy

Mojodi, Alireza, ROUHI, LEILA, & Khashei Varnamkhasti, Khalil. (2021). Effect of citric acid on p53 and p21 genes expression of the human colorectal Adenocarcinoma cell line. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, 8(4 ), 1-9. SID. https://sid.ir/paper/371198/en

Vancouver: Copy

Mojodi Alireza, ROUHI LEILA, Khashei Varnamkhasti Khalil. Effect of citric acid on p53 and p21 genes expression of the human colorectal Adenocarcinoma cell line. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;8(4 ):1-9. Available from: https://sid.ir/paper/371198/en

IEEE: Copy

Alireza Mojodi, LEILA ROUHI, and Khalil Khashei Varnamkhasti, “Effect of citric acid on p53 and p21 genes expression of the human colorectal Adenocarcinoma cell line,” JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 4 , pp. 1–9, 2021, [Online]. Available: https://sid.ir/paper/371198/en

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