EVALUATION OF THE CIPROFLOXACIN EFFECT ON RESISTANT ISOLATES OF PSEUDOMONAS AERUGINOSA IN IN-VITRO AND IN-VIVO

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHABANI A.A.; MAHSOOMI N.; ALE AGHA S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2000 | Volume:1 | Issue:3 Page(s): 39-46

Download Full-Text

Persian Verion

View:

983

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF THE CIPROFLOXACIN EFFECT ON RESISTANT ISOLATES OF PSEUDOMONAS AERUGINOSA IN IN-VITRO AND IN-VIVO

Author(s)

SHABANI A.A. | MAHSOOMI N. | ALE AGHA S. | Issue Writer Certificate

Keywords

RESISTANCEQ3

ANTIBIOTICQ3

CIPROFLOXACINEQ3

PSEUDOMONAS AERUGINOSAQ2

Abstract

Introduction. Pseudomonal infections frequently responds poorly to conventional therapy. Ciprofloxacin, a bactericidal 4-quinolone, has a high activity against a broad spectrum of bacteria including PSEUDOMONAS AERUGINOSA.Materials and Methods. 112 resistant isolates of P.aeruginosa were collected from five hospitals in Tehran. After confirming them by the most specific bacteriological tests such as cultured on Skim milk agar and etc, the efficacy of ciprofloxacin evaluated in comparison with 11 other antipseudomonal ANTIBIOTICs on 103 confirmed resistant isolates. Susceptibility tests were performed by disk-diffusion (BAUER-KIRBY) and Micro dilution broth methods. The therapeutic effects of ciprofloxacin in comparison with the others were studied in experimental infectious model. The ED50 were determined by sperman-Karbers method.Results. Ciprofloxacin was the most active agent against all isolates of P.aeruginosa that tested in in-vitro. The geometric mean (GM) MICs and ranges of ciprofloxacin was 1 and <0.015 to 2hg/ml. In-vivo protective efficacy of ciprofloxacin by intravenus (IV) injection was higher than those of the other agents tested in a mouse model of intraperitoneally inoculated infection caused by P.aeruginosa. Other agents did not exhibit comparable to that of ciprofloxacin in the same model of infection caused by P.aeruginosa.Conclution. The susceptibility profile of individual isolates of each hospital differs only a little, but differs more than the others. Thus, treatment programs of infectious diseases must be designed best on the individual hospital to control the ANTIBIOTIC RESISTANCE.

Cites

BACTERIOLOGY OF HOSPITAL-ACQUIRED INFECTION AND ANTIBIOTIC RESISTANCE IN A HOSPITAL UNIVERSITY OF BUSHEHR PORT "FATEMEH ZAHRA (S)" IN 2002-2003

References

Cite

APA: Copy

SHABANI, A.A., MAHSOOMI, N., & ALE AGHA, S.. (2000). EVALUATION OF THE CIPROFLOXACIN EFFECT ON RESISTANT ISOLATES OF PSEUDOMONAS AERUGINOSA IN IN-VITRO AND IN-VIVO. KOOMESH, 1(3), 39-46. SID. https://sid.ir/paper/37138/en

Vancouver: Copy

SHABANI A.A., MAHSOOMI N., ALE AGHA S.. EVALUATION OF THE CIPROFLOXACIN EFFECT ON RESISTANT ISOLATES OF PSEUDOMONAS AERUGINOSA IN IN-VITRO AND IN-VIVO. KOOMESH[Internet]. 2000;1(3):39-46. Available from: https://sid.ir/paper/37138/en

IEEE: Copy

A.A. SHABANI, N. MAHSOOMI, and S. ALE AGHA, “EVALUATION OF THE CIPROFLOXACIN EFFECT ON RESISTANT ISOLATES OF PSEUDOMONAS AERUGINOSA IN IN-VITRO AND IN-VIVO,” KOOMESH, vol. 1, no. 3, pp. 39–46, 2000, [Online]. Available: https://sid.ir/paper/37138/en

Related Journal Papers