THERAPEUTIC EFFECTS OF CURCUMIN ON RENAL TISSUE DAMAGES INDUCED BY ISCHEMIA REPERFUSION IN RAT

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NAJAFI HOUSHANG; CHANGIZI ASHTIYANI SAEED; MADANI SEYED HAMID; FAKHRI SAJAD; MOHAMADI YARIJANI ZEYNAB; HAZEM MEHDI

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Journal: Koomesh Year:2015 | Volume:16 | Issue:2 (54) Page(s): 273-281

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Title

THERAPEUTIC EFFECTS OF CURCUMIN ON RENAL TISSUE DAMAGES INDUCED BY ISCHEMIA REPERFUSION IN RAT

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Keywords

CURCUMINQ1

ACUTE KIDNEY INJURYQ2

ISCHEMIA/REPERFUSIONQ2

REPERFUSION INJURYQ2

RATQ1

Abstract

Introduction: CURCUMIN has anti-inflammatory and anti-oxidative properties, and the aim of this study was to investigate the therapeutic effects of CURCUMIN on tissue damages induced by renal ISCHEMIA/REPERFUSION.Materials and Methods: In this research, male Wistar RATs were studied in 9 groups which were include sham with 24h reperfusion period, ischemia followed by 24h reperfusion, ISCHEMIA/REPERFUSION-24h which received a single dose 10, 20, or 30 mg/kg (i.p), CURCUMIN 30 min after ischemia, sham with 72h reperfusion period, ischemia followed by 72h reperfusion, ISCHEMIA/REPERFUSION-72h which received a single dose 20 mg/kg (i.p), CURCUMIN and ISCHEMIA/REPERFUSION-72h which received three doses of CURCUMIN (20 mg/kg, i.p) every 24 hours. At the end of reperfusion period, the left kidney tissue were collected and after staining with hematoxylin-eosin, subjected to microscopic study.Results: ISCHEMIA/REPERFUSION leads to increased Bowman's space size, tubular necrosis, vascular congestion and intra-tubular proteinaceous casts in kidney; which CURCUMIN therapy could partially improve all of them. But its effect in groups with 72h reperfusion period and receiving 3 dose of CURCUMIN was significantly greater than those received single dose and 24h reperfusion in comparison with their own sham groups.Conclusion: The results of this study demonstrated that three successive doses of CURCUMIN can be more effective than single-dose treatment on tissue damages resulting from renal ISCHEMIA/REPERFUSION in RAT.

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APA: Copy

NAJAFI, HOUSHANG, CHANGIZI ASHTIYANI, SAEED, MADANI, SEYED HAMID, FAKHRI, SAJAD, MOHAMADI YARIJANI, ZEYNAB, & HAZEM, MEHDI. (2015). THERAPEUTIC EFFECTS OF CURCUMIN ON RENAL TISSUE DAMAGES INDUCED BY ISCHEMIA REPERFUSION IN RAT. KOOMESH, 16(2 (54)), 273-281. SID. https://sid.ir/paper/37158/en

Vancouver: Copy

NAJAFI HOUSHANG, CHANGIZI ASHTIYANI SAEED, MADANI SEYED HAMID, FAKHRI SAJAD, MOHAMADI YARIJANI ZEYNAB, HAZEM MEHDI. THERAPEUTIC EFFECTS OF CURCUMIN ON RENAL TISSUE DAMAGES INDUCED BY ISCHEMIA REPERFUSION IN RAT. KOOMESH[Internet]. 2015;16(2 (54)):273-281. Available from: https://sid.ir/paper/37158/en

IEEE: Copy

HOUSHANG NAJAFI, SAEED CHANGIZI ASHTIYANI, SEYED HAMID MADANI, SAJAD FAKHRI, ZEYNAB MOHAMADI YARIJANI, and MEHDI HAZEM, “THERAPEUTIC EFFECTS OF CURCUMIN ON RENAL TISSUE DAMAGES INDUCED BY ISCHEMIA REPERFUSION IN RAT,” KOOMESH, vol. 16, no. 2 (54), pp. 273–281, 2015, [Online]. Available: https://sid.ir/paper/37158/en

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