Comparison of Serum Level and IL-18 Gene Expression and Reactive Protein in Patients with Type 2 Diabetes with Metabolic Syndrome and Healthy People

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Yadolahifarsani L.; Ziajahromi N.; Vaezipour M.

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Journal: Journal of Ilam University of Medical Sciences Year:2019 | Volume:27 | Issue:3 Page(s): 173-182

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Title

Comparison of Serum Level and IL-18 Gene Expression and Reactive Protein in Patients with Type 2 Diabetes with Metabolic Syndrome and Healthy People

Author(s)

Yadolahifarsani L. | Ziajahromi N. | Vaezipour M. | Issue Writer Certificate

Keywords

Interleukin 18Q1

C-reactive proteinQ1

Type II diabetesQ1

Metabolic syndromeQ1

Abstract

Introduction: Metabolic syndrome is a common clinical anomaly, with an increased risk of developing type 2 diabetes and cardiovascular risk factors. Increased inflammatory mediators, such as reactive protein, as well as the inflammatory cytokines can be associated with the incidence and progression of metaboli syndrome and type 2 diabetes. Materials & Methods: This study was performed on 35 male and female patients with an average age of 55 years, type 2 diabetes mellitus with Metabolic syndrome and 35 healthy subjects as control group. Separated serum samples were kept at-20 ° C for quantitative evaluation of serum IL-18 by ELISA kit and C-reactive protein. RNA extraction from cells was performed by JenaBioscience kit and finally Gene expression assay was performed quantitatively using Real Time RTPCR. Findings: The mean serum levels of IL-18 were significantly increased (P=0. 008), and serum reactive protein (P<0. 001) was significantly increased in patients with type 2 diabetes mellitus with Metabolic syndrome compared with healthy subjects. Also, expression of IL-18 gene (P=0. 003) in lymphocyte cells of Type II diabetes patients with Metabolic syndrome was significantly higher than healthy subjects. Discussion & Conclusions: The present study showed that patients with type 2 diabetes mellitus with Metabolic syndrome have high levels of inflammatory factors such as IL-18 in their serum. it can be concluded that serum levels of IL-18, Creactive protein and IL-18 expression play an important role in inflammatory response and progression. Type 2 diabetes and Metabolic syndrome.

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APA: Copy

Yadolahifarsani, L., Ziajahromi, N., & Vaezipour, M.. (2019). Comparison of Serum Level and IL-18 Gene Expression and Reactive Protein in Patients with Type 2 Diabetes with Metabolic Syndrome and Healthy People. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 27(3 ), 173-182. SID. https://sid.ir/paper/372606/en

Vancouver: Copy

Yadolahifarsani L., Ziajahromi N., Vaezipour M.. Comparison of Serum Level and IL-18 Gene Expression and Reactive Protein in Patients with Type 2 Diabetes with Metabolic Syndrome and Healthy People. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(3 ):173-182. Available from: https://sid.ir/paper/372606/en

IEEE: Copy

L. Yadolahifarsani, N. Ziajahromi, and M. Vaezipour, “Comparison of Serum Level and IL-18 Gene Expression and Reactive Protein in Patients with Type 2 Diabetes with Metabolic Syndrome and Healthy People,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 3 , pp. 173–182, 2019, [Online]. Available: https://sid.ir/paper/372606/en

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