ENHANCED PERMEABILITY OF GENTAMICIN SULFATE THROUGH SHED SNAKE-SKIN AND LIPOSOMAL MEMBRANES BY DIFFERENT ENHANCERS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOGHIMIPOUR E.; SAJADI TABASSI S.A.; RAMEZANI MOHAMMAD; LOBENBERG R.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2003 | Volume:6 | Issue:1 (17) Page(s): 9-19

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,942

Download:

2,464

Cites:

Information Journal Paper

Title

ENHANCED PERMEABILITY OF GENTAMICIN SULFATE THROUGH SHED SNAKE-SKIN AND LIPOSOMAL MEMBRANES BY DIFFERENT ENHANCERS

Author(s)

MOGHIMIPOUR E. | SAJADI TABASSI S.A. | RAMEZANI MOHAMMAD | LOBENBERG R. | Issue Writer Certificate

Keywords

ABSORPTION ENHANCERQ4

ACANTHOPHYLLUM SQUARROSUMQ3

SAPONINQ4

LIPOSOMEQ2

Abstract

The current work provides information on the surfactant induced membrane permeability. The membrane model was a Franz diffusion cell with shed snake-skin as membrane. Also, LIPOSOMEs made by cholesterol and phosphatidylcholine, prepared by freeze-thawing method were tested as synthetic lipid membrane models. Three hydrophilic molecules, gentamicin sulfate, 5(6)-carboxyfluoresceine and phenol red were used as drug models. ABSORPTION ENHANCERs were sodium lauryl sulfate (SLS), benzalkonium choride (BC), that are anionic and cationic surfactants, respectively, and Quillaja saponaria (QTS) and Acanthophyllum squarrusom (ATS) total SAPONINs, two naturally origmated enhancers. Surface tension changes and hemolytic activities were also determined to find out any probable relationship between surfactant properties and its enhancingactivity. The obtained results showed that maximum enhancing effect occured below the surfactant critical micelle concentration (cmc), while they reach their maximum hemolytic activity with concentrations more than their cmc. The results also indicated that there was no enhancing effect induced by benzalkonium choride when applied on the skin model, probably due to the similarity of electric charges on the skin surface and surfactant ions. Among surfactants tested, SLS showed maximum enhancing effect in the diffusion cell model, while benzalkonium choride had maximum activity in LIPOSOME membrane model. Both QTS and ATS showed a moderate activity in both diffusion cell and LIPOSOME models. The precise enhancement mechanism of surfactants tested in this study is not clearly known.

Cites

No record.

References

No record.

Cite

APA: Copy

MOGHIMIPOUR, E., SAJADI TABASSI, S.A., RAMEZANI, MOHAMMAD, & LOBENBERG, R.. (2003). ENHANCED PERMEABILITY OF GENTAMICIN SULFATE THROUGH SHED SNAKE-SKIN AND LIPOSOMAL MEMBRANES BY DIFFERENT ENHANCERS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 6(1 (17)), 9-19. SID. https://sid.ir/paper/372867/en

Vancouver: Copy

MOGHIMIPOUR E., SAJADI TABASSI S.A., RAMEZANI MOHAMMAD, LOBENBERG R.. ENHANCED PERMEABILITY OF GENTAMICIN SULFATE THROUGH SHED SNAKE-SKIN AND LIPOSOMAL MEMBRANES BY DIFFERENT ENHANCERS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2003;6(1 (17)):9-19. Available from: https://sid.ir/paper/372867/en

IEEE: Copy

E. MOGHIMIPOUR, S.A. SAJADI TABASSI, MOHAMMAD RAMEZANI, and R. LOBENBERG, “ENHANCED PERMEABILITY OF GENTAMICIN SULFATE THROUGH SHED SNAKE-SKIN AND LIPOSOMAL MEMBRANES BY DIFFERENT ENHANCERS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 6, no. 1 (17), pp. 9–19, 2003, [Online]. Available: https://sid.ir/paper/372867/en

Related Journal Papers