EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VACCINIUM ARCTOSTAPHYLOS ON INSULIN RELEASE FROM RAT-ISOLATED LANGERHANS ISLETS

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SHAFIEI NICK R.; PARIZADEH S.M.R.; ZOKAEI N.; GHORBANI AHMAD

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Journal: Koomesh Year:2011 | Volume:12 | Issue:4 (40) Page(s): 435-440

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Title

EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VACCINIUM ARCTOSTAPHYLOS ON INSULIN RELEASE FROM RAT-ISOLATED LANGERHANS ISLETS

Author(s)

SHAFIEI NICK R. | PARIZADEH S.M.R. | ZOKAEI N. | GHORBANI AHMAD | Issue Writer Certificate

Keywords

VACCINIUM ARCTOSTAPHYLOSQ1

HYDRO-ALCOHOLIC EXTRACTQ3

INSULINQ2

LANGERHANS ISLETSQ2

RATQ2

Abstract

Introduction: VACCINIUM ARCTOSTAPHYLOS is one of the medicinal plants used in the treatment of diabetes. But the mechanisms responsible for its antidiabetic action have not been well defined. This study was undertaken to investigate the possible effect of V. arctostaphylos on INSULIN release from RATisolated LANGERHANS ISLETS.Materials and Methods: The islets were incubated in the presence of 3 or 10 mM glucose with or without milrinone (0.1 and 0.01%) and HYDRO-ALCOHOLIC EXTRACT of V. arctostaphylos (0.1 and 0.1%) for 60 min. The concentration of INSULIN was measured in samples of incubation medium.Results: The increase of glucose concentration in incubation medium from 3 to 10 mM resulted in a significant increase of INSULIN secretion. Milrinone at 0.1 mM significantly increased INSULIN release evoked by 10 mM glucose. However, none of the extract concentrations affected the INSULIN release. Conclusion: Our data demonstrated that V. arctostaphylos had no INSULINotropic property and its effects on diabetes mediated by other mechanisms which should be clarified in future studies.

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APA: Copy

SHAFIEI NICK, R., PARIZADEH, S.M.R., ZOKAEI, N., & GHORBANI, AHMAD. (2011). EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VACCINIUM ARCTOSTAPHYLOS ON INSULIN RELEASE FROM RAT-ISOLATED LANGERHANS ISLETS. KOOMESH, 12(4 (40)), 435-440. SID. https://sid.ir/paper/372922/en

Vancouver: Copy

SHAFIEI NICK R., PARIZADEH S.M.R., ZOKAEI N., GHORBANI AHMAD. EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VACCINIUM ARCTOSTAPHYLOS ON INSULIN RELEASE FROM RAT-ISOLATED LANGERHANS ISLETS. KOOMESH[Internet]. 2011;12(4 (40)):435-440. Available from: https://sid.ir/paper/372922/en

IEEE: Copy

R. SHAFIEI NICK, S.M.R. PARIZADEH, N. ZOKAEI, and AHMAD GHORBANI, “EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF VACCINIUM ARCTOSTAPHYLOS ON INSULIN RELEASE FROM RAT-ISOLATED LANGERHANS ISLETS,” KOOMESH, vol. 12, no. 4 (40), pp. 435–440, 2011, [Online]. Available: https://sid.ir/paper/372922/en

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