EFFECTS OF ANGIOTENSIN II ON EXPRESSION OF α3, αV AND 3 INTEGRIN PROTEINS IN B16-F10 MELANOMA CELLS

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ESFANDIARY YEGANEH NEWSHA; GALUSTANIAN NAZENIK; NASIRZADEH GOLJAHI AIDA; GHODRATI MARYAM; BOGHOZIAN ROOBINA; RASOULI ELHAM; ABBASI ELHAM; GHORBAN DADRASS ORKIDEH; MOHAMMAD AKHAVAN MAZIAR

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Title

EFFECTS OF ANGIOTENSIN II ON EXPRESSION OF α3, αV AND 3 INTEGRIN PROTEINS IN B16-F10 MELANOMA CELLS

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Keywords

MELANOMAQ2

INTEGRINQ2

ANGIOTESNIN IIQ3

LOSARTANQ3

Abstract

Introduction: Several reports indicated the role of angiotensin II antagonists in suppression of different tumvors. Some of the recent studies point to the increasing effect of angiotensin II on expression of important factors regarding to the tumor growth. Also the role of INTEGRINs in growth and metastasis of tumoral cells is very important but the role of angiotensin II in the expression of INTEGRINs is not clear yet.Materials and Methods: MELANOMA tumors were induced in C57 mice using S.C. injections of B16-F10 cells. LOSARTAN was I.P. injected to C57 mice. Also B16-F10 cells were cultured and incubated with angiotensin II with or without LOSARTAN for two hours and the expression of a3, av and b3 INTEGRINs were studied using western blotting.Results: Our results indicate the suppressing role of LOSARTAN on tumor growth (day17, P=0.013; day18:P=0.0015). In addition angiotensin II increased significantly the expression of studied INTEGRINs in B16-F10 cultured cells (integrin aV: P=0.049; INTEGRIN a3: P= 0.016; INTEGRIN b3: P= 0.037), and LOSARTAN completely abolished this effect.Conclusion: The role of angiotensin II in tumor growth may be because of reasons including its role in elevating the expression levels of a3, av and 3 INTEGRINs. In animal model of MELANOMA, LOSARTAN suppressed the tumor growth through AT1 receptors inhibition. The present study indicates the importance of the drugs such as LOSARTAN besides the standard therapeutic approach for tumors.

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APA: Copy

ESFANDIARY YEGANEH, NEWSHA, GALUSTANIAN, NAZENIK, NASIRZADEH GOLJAHI, AIDA, GHODRATI, MARYAM, BOGHOZIAN, ROOBINA, RASOULI, ELHAM, ABBASI, ELHAM, GHORBAN DADRASS, ORKIDEH, & MOHAMMAD AKHAVAN, MAZIAR. (2013). EFFECTS OF ANGIOTENSIN II ON EXPRESSION OF α3, αV AND 3 INTEGRIN PROTEINS IN B16-F10 MELANOMA CELLS. KOOMESH, 14(4 (48)), 396-403. SID. https://sid.ir/paper/37297/en

Vancouver: Copy

ESFANDIARY YEGANEH NEWSHA, GALUSTANIAN NAZENIK, NASIRZADEH GOLJAHI AIDA, GHODRATI MARYAM, BOGHOZIAN ROOBINA, RASOULI ELHAM, ABBASI ELHAM, GHORBAN DADRASS ORKIDEH, MOHAMMAD AKHAVAN MAZIAR. EFFECTS OF ANGIOTENSIN II ON EXPRESSION OF α3, αV AND 3 INTEGRIN PROTEINS IN B16-F10 MELANOMA CELLS. KOOMESH[Internet]. 2013;14(4 (48)):396-403. Available from: https://sid.ir/paper/37297/en

IEEE: Copy

NEWSHA ESFANDIARY YEGANEH, NAZENIK GALUSTANIAN, AIDA NASIRZADEH GOLJAHI, MARYAM GHODRATI, ROOBINA BOGHOZIAN, ELHAM RASOULI, ELHAM ABBASI, ORKIDEH GHORBAN DADRASS, and MAZIAR MOHAMMAD AKHAVAN, “EFFECTS OF ANGIOTENSIN II ON EXPRESSION OF α3, αV AND 3 INTEGRIN PROTEINS IN B16-F10 MELANOMA CELLS,” KOOMESH, vol. 14, no. 4 (48), pp. 396–403, 2013, [Online]. Available: https://sid.ir/paper/37297/en

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