THE CHANGES OF αV, β3, α4, β1 INTEGRINS EXPRESSION AND OSTEOPONTIN THEIR LIGANDS IN MURINE ESTROUS CYCLE

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PEYGHAMBARI F.; SALEHNIA M.; REZAZADEH VALOUJERDI M.; FOROUZANDEH MAHDI

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Journal: Pathobiology Research Year:2009 | Volume:11 | Issue:3-4 Page(s): 1-7

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Title

THE CHANGES OF αV, β3, α4, β1 INTEGRINS EXPRESSION AND OSTEOPONTIN THEIR LIGANDS IN MURINE ESTROUS CYCLE

Author(s)

PEYGHAMBARI F. | SALEHNIA M. | REZAZADEH VALOUJERDI M. | FOROUZANDEH MAHDI | Issue Writer Certificate

Keywords

ENDOMETRIALQ3

INTEGRINQ3

ESTROUS CYCLEQ3

IMMUNOHISTOCHEMISTRYQ3

Abstract

Objective: Considering the importance of INTEGRIN molecules in the implantation and lack of sufficient information in the expression pattern of these molecules in various phases of ESTROUS CYCLE. It seemed to be necessary to investigate these molecules in mouse ENDOMETRIAL during the various phases of oestrous cycle. Materials and Methods: Female NMRI mice (n=15) aged 6-8 weeks were studied. Various phases of ESTROUS CYCLE including: proestrus, estrus, metestrus and diestrus were determined by vaginal smear. The mice were sacrificed (at least 3 per each phase) by cervical dislocation and the tissues were obtained from the middle 1/3 part of their uterine horns at each phase then the cryosections at thicknesses between 8-10 m were obtained. Then the IMMUNOHISTOCHEMISTRY were done for INTEGRINs of 4, b1, av, b3 and their ligand osteopontine. Results: The INTEGRINs were expressed only in the metestrous phase of oestrous cycle in the different locations of mouse endometrium. The positive reactions were observed for av, a4 and b3 in the apical and basal membrane of glandular epithelium. Also the positive reaction for b1 was found in surface and glandular epithelium as well as stroma. The osteopontin expression was seen in the apical membranes of surface and glandular epithelium and was not seen in other locations. Conclusion: It seems that expression of INTEGRINs in endometrium is based on their role in the implantation, therefore the molecules a4, b1 and OPN that are expressed on the surface epithelial may be involve in the adhesion of cell to cell and INTEGRINs of av, b3 that are expressed in the glandular epithelium and stroma involve in the invasion of embryo.

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APA: Copy

PEYGHAMBARI, F., SALEHNIA, M., REZAZADEH VALOUJERDI, M., & FOROUZANDEH, MAHDI. (2009). THE CHANGES OF αV, β3, α4, β1 INTEGRINS EXPRESSION AND OSTEOPONTIN THEIR LIGANDS IN MURINE ESTROUS CYCLE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 11(3-4), 1-7. SID. https://sid.ir/paper/81086/en

Vancouver: Copy

PEYGHAMBARI F., SALEHNIA M., REZAZADEH VALOUJERDI M., FOROUZANDEH MAHDI. THE CHANGES OF αV, β3, α4, β1 INTEGRINS EXPRESSION AND OSTEOPONTIN THEIR LIGANDS IN MURINE ESTROUS CYCLE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2009;11(3-4):1-7. Available from: https://sid.ir/paper/81086/en

IEEE: Copy

F. PEYGHAMBARI, M. SALEHNIA, M. REZAZADEH VALOUJERDI, and MAHDI FOROUZANDEH, “THE CHANGES OF αV, β3, α4, β1 INTEGRINS EXPRESSION AND OSTEOPONTIN THEIR LIGANDS IN MURINE ESTROUS CYCLE,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 11, no. 3-4, pp. 1–7, 2009, [Online]. Available: https://sid.ir/paper/81086/en

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