IDENTIFYING DIFFERENTIALLY EXPRESSED GENES BASED ON THEIR EXPRESSIONS IN LEUKEMIA

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AZADI N.A.; NOURI JELIANI K.A.; TAHERI KALANI M.

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Journal: Koomesh Year:2005 | Volume:6 | Issue:4 Page(s): 259-264

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Title

IDENTIFYING DIFFERENTIALLY EXPRESSED GENES BASED ON THEIR EXPRESSIONS IN LEUKEMIA

Author(s)

AZADI N.A. | NOURI JELIANI K.A. | TAHERI KALANI M. | Issue Writer Certificate

Keywords

DNA MICRO ARRAYQ4

GENE EXPRESSIONQ2

GENE SELECTIONQ3

LEUKEMIAQ4

WESTFALL & YANGQ4

Abstract

Introduction: In 1999, Golub invented a new reasonable and more efficient approach to recognize acute LEUKEMIA cases based on GENE EXPRESSION data. Studying on 6817 genes derived from 38 patients, they finally introduce a complex inventory statistical method to diagnose LEUKEMIA patients in earlier stage. Their result was absolutely outstanding, without any mistake in patient diagnosis; the result perfectly (100%) assigned tumors to known classes correctly. Here, in this study, we want to introduce a simpler method to distinguish Differentially Expressed (DE) genes and use Golub approach as a test case to evaluate our results.Materials and Methods: We used the same data as Golub study that were produced by oligonucleotide microarry. Several statistical methods such as t-test, Wilcoxon test and permutation test were applied to identify DEs. Results: The Westfall and Yang based on t- statistic at significant level .015 (α= 0.015) recognized 48 genes significant (or DE). Of those 28 genes (58%) were exactly similar to Golub study and the rest, 20 genes (42%), were different. However, with these 48 genes, the result of assigning tumors to known classes is completely as identical as that of of Golub study.Conclusion: The result of assigning tumors to known classes with these 48 genes is completely as identical as that of Golub study.

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APA: Copy

AZADI, N.A., NOURI JELIANI, K.A., & TAHERI KALANI, M.. (2005). IDENTIFYING DIFFERENTIALLY EXPRESSED GENES BASED ON THEIR EXPRESSIONS IN LEUKEMIA. KOOMESH, 6(4), 259-264. SID. https://sid.ir/paper/37348/en

Vancouver: Copy

AZADI N.A., NOURI JELIANI K.A., TAHERI KALANI M.. IDENTIFYING DIFFERENTIALLY EXPRESSED GENES BASED ON THEIR EXPRESSIONS IN LEUKEMIA. KOOMESH[Internet]. 2005;6(4):259-264. Available from: https://sid.ir/paper/37348/en

IEEE: Copy

N.A. AZADI, K.A. NOURI JELIANI, and M. TAHERI KALANI, “IDENTIFYING DIFFERENTIALLY EXPRESSED GENES BASED ON THEIR EXPRESSIONS IN LEUKEMIA,” KOOMESH, vol. 6, no. 4, pp. 259–264, 2005, [Online]. Available: https://sid.ir/paper/37348/en

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