The Role of Central Nervous System and Hypothalamic-Pituitary-Gonadal (HPG) Axis Changes in the Occurrence of Polycystic Ovary Syndrome: A Narrative Review Article

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SARAHIAN N.; NOROOZZADEH M.; Changaei M.; RAMEZANI TEHRANI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Rafsanjan University of Medical Sciences Year:2020 | Volume:19 | Issue:7 Page(s): 727-748

Download Full-Text

Persian Verion

View:

1,097

Download:

Cites:

Information Journal Paper

Title

The Role of Central Nervous System and Hypothalamic-Pituitary-Gonadal (HPG) Axis Changes in the Occurrence of Polycystic Ovary Syndrome: A Narrative Review Article

Author(s)

SARAHIAN N. | NOROOZZADEH M. | Changaei M. | RAMEZANI TEHRANI F. | Issue Writer Certificate

Keywords

Central nervous system (CNS)Q3

HyperandrogenismQ1

Polycystic ovary syndromeQ2

GonadQ2

Abstract

Background and Objectives: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women in reproductive age. It is associated with Hyperandrogenism, obesity, menstrual iregularity and infertility. There are several hypotheses regarding the metabolic, genetic, epigenetic, and environmental causes of the disease. Although the main cause of the disease is not well known, it seems that the disorder in the central nervous system (CNS) and as a result, the disruption in the production of Gonadal hormones is one of the main causes of this syndrome. The relationship between CNS and Gonadal steroid hormones is bilateral. As dysfunction of this system plays a role in the development of the disease, alterations in the levels of steroid hormones also affect the activity and flexibility of neuronal connections in the brain. Androgens also send critical feedback to the hypothalamus and pituitary glands and regulate the secretion of GnRH (Gonadotropin-releasing hormone). Androgens can disrupt the neuroendocrine reproductive axis by altering the central circuits of the brain. Prescribing drugs against neuronal phenotypes that potentially stimulate excessive GnRH / LH (Luteinizing hormone) secretion could be a new and selective approach to reducing LH frequency in women with PCOS.

Cites

No record.

References

Cite

APA: Copy

SARAHIAN, N., NOROOZZADEH, M., Changaei, M., & RAMEZANI TEHRANI, F.. (2020). The Role of Central Nervous System and Hypothalamic-Pituitary-Gonadal (HPG) Axis Changes in the Occurrence of Polycystic Ovary Syndrome: A Narrative Review Article. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 19(7 ), 727-748. SID. https://sid.ir/paper/373572/en

Vancouver: Copy

SARAHIAN N., NOROOZZADEH M., Changaei M., RAMEZANI TEHRANI F.. The Role of Central Nervous System and Hypothalamic-Pituitary-Gonadal (HPG) Axis Changes in the Occurrence of Polycystic Ovary Syndrome: A Narrative Review Article. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;19(7 ):727-748. Available from: https://sid.ir/paper/373572/en

IEEE: Copy

N. SARAHIAN, M. NOROOZZADEH, M. Changaei, and F. RAMEZANI TEHRANI, “The Role of Central Nervous System and Hypothalamic-Pituitary-Gonadal (HPG) Axis Changes in the Occurrence of Polycystic Ovary Syndrome: A Narrative Review Article,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 19, no. 7 , pp. 727–748, 2020, [Online]. Available: https://sid.ir/paper/373572/en

Related Journal Papers