Study of Protective Effect of Nigella Sativa Nanocapsules on Tissue Pathology and IL-10 levels in Lung Tissues Exposed to NNK

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BARZEGARI A.; MIRDAR SH.

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Journal: Pathobiology Research Year:2019 | Volume:22 | Issue:1 Page(s): 35-40

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Information Journal Paper

Title

Study of Protective Effect of Nigella Sativa Nanocapsules on Tissue Pathology and IL-10 levels in Lung Tissues Exposed to NNK

Author(s)

BARZEGARI A. | MIRDAR SH. | Issue Writer Certificate

Keywords

Nigella SativaQ1

NanocapsulesQ1

IL-10Q1

NNKQ1

Histologic StructureQ1

Abstract

Aims It is assumed that nitrosamine ketone derived from tobacco (NNK) which is the most important carcinogen in tobacco modulates alveolar macrophage mediator production, such as anti-inflammatory cytokine IL-10. The aims of this study were to investigate the effect of a Nigella Sativa on tissue pathology and IL-10 levels in lung tissues exposed to NNK Materials & Methods In this experimental study, 46 Wistar rats were randomly divided into five groups consist of supplement, supplement+NNK, NNK, solvent and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12. 5 mg per kg body weight. Supplemented groups also consumed Nigella Sativa Nanocapsules for 12 weeks. Levels of IL-10 in homogenized lung tissue were measured by ELISA. To analyze the data; ANOVA and Tukey test were used at a significance level of p≤ 0. 05. Findings Exposure to NNK increased levels of IL-10 compared with the solvent group, although not statistically significant (p≥ 0. 05). Meanwhile, a period of consumption of Nigella Sativa Nanocapsules significantly increased levels of IL-10 in NNK + supplement and the supplement groups compared to NNK group (p=0. 038, p=0. 002; respectively). In addition, the effect of Nigella Sativa Nanocapsules on IL-10 levels of lung tissue was shown that the levels of this variable were significantly higher than the solvent group (p=0. 001). Conclusion Generally it could be confirmed that consumption of Nigella Sativa Nanocapsules plays an important role in the inhibition of inflammation induced by NNK via Increase of IL-10 activity.

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APA: Copy

BARZEGARI, A., & MIRDAR, SH.. (2019). Study of Protective Effect of Nigella Sativa Nanocapsules on Tissue Pathology and IL-10 levels in Lung Tissues Exposed to NNK. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 22(1 ), 35-40. SID. https://sid.ir/paper/373584/en

Vancouver: Copy

BARZEGARI A., MIRDAR SH.. Study of Protective Effect of Nigella Sativa Nanocapsules on Tissue Pathology and IL-10 levels in Lung Tissues Exposed to NNK. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2019;22(1 ):35-40. Available from: https://sid.ir/paper/373584/en

IEEE: Copy

A. BARZEGARI, and SH. MIRDAR, “Study of Protective Effect of Nigella Sativa Nanocapsules on Tissue Pathology and IL-10 levels in Lung Tissues Exposed to NNK,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 22, no. 1 , pp. 35–40, 2019, [Online]. Available: https://sid.ir/paper/373584/en

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