NEUROPROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND HYDROALCOHOLIC EXTRACTION OF ERIOBOTRYA JAPONICA ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS

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FALLAH MOHAMMADI ZIA; HAJIZADEH MOGHADDAM AKBAR; AGHASI MOHAMMAD; ESMAEILI AMIR HOSSEIN

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Journal: Koomesh Year:2013 | Volume:15 | Issue:1 (49) Page(s): 31-38

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Title

NEUROPROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND HYDROALCOHOLIC EXTRACTION OF ERIOBOTRYA JAPONICA ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS

Author(s)

FALLAH MOHAMMADI ZIA | HAJIZADEH MOGHADDAM AKBAR | AGHASI MOHAMMAD | ESMAEILI AMIR HOSSEIN | Issue Writer Certificate

Keywords

ERIOBOTRYA JAPONICAQ2

EXERCISE THERAPYQ2

6-HYDROXYDOPAMINEQ2

TYROSINE HYDROXYLASEQ2

DOPAMINEQ2

STRIATUMQ3

PARKINSONQ2

Abstract

Introduction: In this study, we investigated the effects of 12 weeks of voluntary exercise on a running wheel and extraction of plant flowers ERIOBOTRYA JAPONICA on DOPAMINE and TYROSINE HYDROXYLASE in the STRIATUM of PARKINSONian rats.Materials and Methods: Twenty four rats were divided into three groups: control, PARKINSON and PARKINSON + training and extract. To induce PARKINSON, 250 mg/kg of 6-hydroxy DOPAMINE (6-OHDA) (dissolved in saline) was administered into intracerebrovenricular by a stereotaxic apparatus. Training extract group were housed in individual cages with attached running wheels and during study period received 200 mg/kg extract intraperitoneally three times per week. TYROSINE HYDROXYLASE and DOPAMINE levels in the STRIATUM were measured by ELISA.Results: Voluntary wheel running and extract significantly prevent the decrease of DOPAMINE levels in PARKINSONian rats (P=0.001), but TYROSINE HYDROXYLASE level did not change in training-extract group.Conclusion: Our findings show that pre-treatment with voluntary exercise and hydro alcoholic extractions of ERIOBOTRYA JAPONICA have a protective role against 6-OHDA induced toxicity.

Cites

THE PROTECTIVE EFFECTS OF SALVIA OFFICINALIS EXTRACT ON THE PANCREATIC TISSUE OF RATS POISONED BY DIAZINON

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APA: Copy

FALLAH MOHAMMADI, ZIA, HAJIZADEH MOGHADDAM, AKBAR, AGHASI, MOHAMMAD, & ESMAEILI, AMIR HOSSEIN. (2013). NEUROPROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND HYDROALCOHOLIC EXTRACTION OF ERIOBOTRYA JAPONICA ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS. KOOMESH, 15(1 (49)), 31-38. SID. https://sid.ir/paper/37369/en

Vancouver: Copy

FALLAH MOHAMMADI ZIA, HAJIZADEH MOGHADDAM AKBAR, AGHASI MOHAMMAD, ESMAEILI AMIR HOSSEIN. NEUROPROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND HYDROALCOHOLIC EXTRACTION OF ERIOBOTRYA JAPONICA ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS. KOOMESH[Internet]. 2013;15(1 (49)):31-38. Available from: https://sid.ir/paper/37369/en

IEEE: Copy

ZIA FALLAH MOHAMMADI, AKBAR HAJIZADEH MOGHADDAM, MOHAMMAD AGHASI, and AMIR HOSSEIN ESMAEILI, “NEUROPROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND HYDROALCOHOLIC EXTRACTION OF ERIOBOTRYA JAPONICA ON DOPAMINE AND TYROSINE HYDROXYLASE IN THE STRIATUM OF PARKINSONIAN RATS,” KOOMESH, vol. 15, no. 1 (49), pp. 31–38, 2013, [Online]. Available: https://sid.ir/paper/37369/en

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