The effects of endurance exercise training on gene expression of GAP-43 and CAP-1 in cerebellar tissue of male Wistar rats

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JAHANI GOLBAR SHIVA; GAEINI ABBAS ALI; Koushkie Jahromi Maryam; SALESI MOHSEN; NEMATI JAVAD

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Journal: JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT Year:2020 | Volume:7 | Issue:14 Page(s): 57-65

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Title

The effects of endurance exercise training on gene expression of GAP-43 and CAP-1 in cerebellar tissue of male Wistar rats

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Keywords

Endurance exerciseQ2

GAP-43 proteinQ1

CAP-1 proteinQ1

CerebellumQ1

Abstract

Background and Aim: Growth associated protein 43 (GAP-43) and Adenylyl cyclase-associated protein 1 (CAP-1) are related to nerve cells restorations. But the role of physical exercise on these two proteins in Cerebellum has not been clarified yet. The purpose of present study was investigating the influence of six weeks Endurance exercise training on gene expression of GAP-43 and CAP-1 in cerebellar tissue of male Wistar rats. Materials and Methods: Twenty healthy male Wistar rats were selected and divided into two groups of including experimental (n=10) and control (n=10). Experimental group performed aerobic exercise, five days per week for six weeks with the speed of 11-18 m/min for 10-30 minutes. Control group did not have any exercise training program. Real time-PCR and 2-Δ Δ CT were used for biochemistry analysis. Statistical test of Kolmogorov-Smirnov was used for evaluating the data normality, and cosidering the violation of normal distribution, U Mann Whitney test was applied for comparing the groups. Results: Gene expression of GAP-43 (p=0. 002) and CAP-1 (p=0. 002) proteins increased significantly in the experimental compared to control group. Conclusion: Given the important role of GAP-43 and CAP-1 proteins in improving the nervous syetem, it seems that Endurance exercise training can play a key role as a non-invasive method in increasing the gene expression of the proteins in Cerebellum and so recovering and regeneration of cells and improving cerebelluar function.

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APA: Copy

JAHANI GOLBAR, SHIVA, GAEINI, ABBAS ALI, Koushkie Jahromi, Maryam, SALESI, MOHSEN, & NEMATI, JAVAD. (2020). The effects of endurance exercise training on gene expression of GAP-43 and CAP-1 in cerebellar tissue of male Wistar rats. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, 7(14 ), 57-65. SID. https://sid.ir/paper/373842/en

Vancouver: Copy

JAHANI GOLBAR SHIVA, GAEINI ABBAS ALI, Koushkie Jahromi Maryam, SALESI MOHSEN, NEMATI JAVAD. The effects of endurance exercise training on gene expression of GAP-43 and CAP-1 in cerebellar tissue of male Wistar rats. JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT[Internet]. 2020;7(14 ):57-65. Available from: https://sid.ir/paper/373842/en

IEEE: Copy

SHIVA JAHANI GOLBAR, ABBAS ALI GAEINI, Maryam Koushkie Jahromi, MOHSEN SALESI, and JAVAD NEMATI, “The effects of endurance exercise training on gene expression of GAP-43 and CAP-1 in cerebellar tissue of male Wistar rats,” JOURNAL OF PRACTICAL STUDIES AT BIOSCIENCES IN SPORT, vol. 7, no. 14 , pp. 57–65, 2020, [Online]. Available: https://sid.ir/paper/373842/en

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