THE EFFECT OF PIPERINE ON ANALGESIA AND NALOXOANE-INDUCD JUMPING IN MORPHINE DEPENDENT MICE

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MOGHADAMNIA ALI AKBAR; AFRAZ E.

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Journal: Koomesh Year:2000 | Volume:2 | Issue:1 Page(s): 17-24

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Information Journal Paper

Title

THE EFFECT OF PIPERINE ON ANALGESIA AND NALOXOANE-INDUCD JUMPING IN MORPHINE DEPENDENT MICE

Author(s)

MOGHADAMNIA ALI AKBAR | AFRAZ E. | Issue Writer Certificate

Keywords

BLACK PEPPERQ3

PIPERINEQ3

MORPHINEQ3

DEPENDENCYQ2

ANALGESIAQ3

Abstract

Introduction: BLACK PEPPER is usually used in Iranian traditional medicine as a palliative agent. The aim of this study was to investigate the effect of PIPERINE, an effective agent in BLACK PEPPER, on pain sensitivity and also jumping induced by naloxone in MORPHINE dependent mice. Materials and Methods: This randomized experimental study was performed on mice. The animals divided into control (saline) and test (drug) groups. MORPHINE was used to produce drug DEPENDENCY by Marshall method. Tail-flick test was used for evaluation of analgesic effect of the drug. Jumping method was used for measuring intensity of MORPHINE DEPENDENCY. Results: The results show that different doses of PIPERINE alone did not any significant effect on the tail-flick latency, but pretreatment of PIPERINE (25, 50,75 mg/kg) significantly potentiated the analgesic effect of MORPHINE (10 mg/kg) on the 'tail-flick la tency (P < 0.05). Pretreatment of PIPERINE (25, 50, 75 mg/kg) significantly increased that the counts and latency of jumping in MORPHINE-dependent mice in any tested dose, except for dose of 25 mg/kg of PIPERINE which had no effect on jumping latency. Conclusion: The data indicate that PIPERINE itself has no any effect on ANALGESIA and jumping, but potentiated the effect of MORPHINE on the tail-flick latency and also affected MORPHINE DEPENDENCY.

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References

بررسی اثر ضد دردی عصاره هیدروالکلی زنجبیل و فلفل سیاه به روش Tail-Flick در موش سوری

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APA: Copy

MOGHADAMNIA, ALI AKBAR, & AFRAZ, E.. (2000). THE EFFECT OF PIPERINE ON ANALGESIA AND NALOXOANE-INDUCD JUMPING IN MORPHINE DEPENDENT MICE. KOOMESH, 2(1), 17-24. SID. https://sid.ir/paper/37402/en

Vancouver: Copy

MOGHADAMNIA ALI AKBAR, AFRAZ E.. THE EFFECT OF PIPERINE ON ANALGESIA AND NALOXOANE-INDUCD JUMPING IN MORPHINE DEPENDENT MICE. KOOMESH[Internet]. 2000;2(1):17-24. Available from: https://sid.ir/paper/37402/en

IEEE: Copy

ALI AKBAR MOGHADAMNIA, and E. AFRAZ, “THE EFFECT OF PIPERINE ON ANALGESIA AND NALOXOANE-INDUCD JUMPING IN MORPHINE DEPENDENT MICE,” KOOMESH, vol. 2, no. 1, pp. 17–24, 2000, [Online]. Available: https://sid.ir/paper/37402/en

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