Assessment the Genotypes of Carbapenem Resistant Acinetobacter baumannii Isolates Carrying oxa23 Recovered from Clinical Specimens in Selected Hospitals of Tehran

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DOURAGHI MASOUMEH; KARAMI ZARANDI MORTEZA; ALIRAMEZANI AMIR; GHOURCHIAN SEDIGHEH; RAHBAR MOHAMMAD

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2019 | Volume:24 | Issue:86 Page(s): 16-25

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Title

Assessment the Genotypes of Carbapenem Resistant Acinetobacter baumannii Isolates Carrying oxa23 Recovered from Clinical Specimens in Selected Hospitals of Tehran

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Keywords

Acinetobacter baumanniiQ2

carbapenem resistanceQ1

oxa23Q1

Pulsed-Field Gel ElectrophoresisQ1

Abstract

Background and objective: The first imipenem-resistant A. baumannii emerged shortly after the introduction and therapeutic use of carbapenems, particularly imipenem. The resistance to imipenem in this strain was found to be associated with oxa23 which is the most widespread gene conferring resistance to carbapenems. Because of the wide distribution of oxa23 in Iranian isolates, identifying the genotypes of endemic or circulating isolates in hospitals is of prime importance. This study aimed to identify the genotypes of carbapenem resistant A. baumannii isolates carrying oxa23 recovered from clinical specimens in selected hospitals of Tehran. Materials and methods. A set of 92 A. baumannii isolates was collected and identified. Antibiotic susceptibility testing was performed by disk diffusion. A multiplex PCR was done for screening oxa23, oxa24 and oxa58 genes. The genetic pattern of the isolates was identified by Pulsed Field Gel Electrophoresis (PFGE) using ApaI enzyme. Results. Of the 92 isolates, 81 (88%) harbored oxa23. In the current study, 72 distinct pulsotypes were identified and of them 61 pulsotypes contained only one isolate while in the remaining 11 pulsotypes, two or more isolates were clustered. Conclusion. This study showed the polycloncal distribution of the carbapenem resistant A. baumannii isolates carrying oxa23 in selected hospitals. Some of the isolates carrying oxa23 were detected for several months in target hospitals.

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APA: Copy

DOURAGHI, MASOUMEH, KARAMI ZARANDI, MORTEZA, ALIRAMEZANI, AMIR, GHOURCHIAN, SEDIGHEH, & RAHBAR, MOHAMMAD. (2019). Assessment the Genotypes of Carbapenem Resistant Acinetobacter baumannii Isolates Carrying oxa23 Recovered from Clinical Specimens in Selected Hospitals of Tehran. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 24(86 ), 16-25. SID. https://sid.ir/paper/374147/en

Vancouver: Copy

DOURAGHI MASOUMEH, KARAMI ZARANDI MORTEZA, ALIRAMEZANI AMIR, GHOURCHIAN SEDIGHEH, RAHBAR MOHAMMAD. Assessment the Genotypes of Carbapenem Resistant Acinetobacter baumannii Isolates Carrying oxa23 Recovered from Clinical Specimens in Selected Hospitals of Tehran. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2019;24(86 ):16-25. Available from: https://sid.ir/paper/374147/en

IEEE: Copy

MASOUMEH DOURAGHI, MORTEZA KARAMI ZARANDI, AMIR ALIRAMEZANI, SEDIGHEH GHOURCHIAN, and MOHAMMAD RAHBAR, “Assessment the Genotypes of Carbapenem Resistant Acinetobacter baumannii Isolates Carrying oxa23 Recovered from Clinical Specimens in Selected Hospitals of Tehran,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 24, no. 86 , pp. 16–25, 2019, [Online]. Available: https://sid.ir/paper/374147/en

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