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Information Journal Paper

Title

MOLECULAR DETECTION OF ISABA2 AMONG CARBAPENEM HYDROLYZING CLASS D β-LACTAMASESE ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM PATIENTS IN TEHRAN HOSPITALS

Pages

  19-26

Abstract

 Background and Aims: ACINETOBACTER BAUMANNII is an opportunistic pathogen that has acquired a high rate of ANTIBIOTIC RESISTANCE. Identification of the major elements increasing the expression of resistance genes while having a role in their transmission, can help us control the A. baumanniiinfections. This study aimed to determine the prevalence of ISABA2 in A. baumanniistrains which include group D beta-lactamase genes among hospitalized patients.Materials and Methods: From August 2014 to April 2015, 105 A. baumannii strains were collected from different clinical samples of patients in 5 hospitals in Tehran. The confirmation of strains was done by phenotypical tests and existence of blaOXA-51-like gene. Antibiotic susceptibility pattern of the isolates were performed by Disc Diffusion Test (DDT) and Minimum Inhibitory Concentration (MIC) according to the CLSI. ESBL producing strains were recognized with Combined Disc Diffusion Test (CDDT) while the presence of OXA genes and ISAba1and ISABA2 were analyzed using PCR reactions.Results: The result of this study showed that the highest and lowest rates of ANTIBIOTIC RESISTANCE belonged to cefotaxim (100%) and colistin (99.05%), respectively. A total of 55 isolates (54.5%) were capable of producing ESBL. Unlike theblaOXA-58-like gene, which was not found in any of the isolates, blaOXA-51-like- was present among all the isolates. Prevalence of blaOXA-23-like and blaOXA-24-like genes were 103 (98.09%) and 68 (64.76%), respectively and the frequency ofISAba1 and ISABA2 were 105 (100%) and 97 (92.36%), respectively.Conclusions: The existence of additional elements as effective factors, can increase the expression of resistance genes and, therefore, help them to be mobile and transmitted between bacteria. Determination of these elements is, therefore, necessary for controlling infections.

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    APA: Copy

    OWRANG, MINA, ESLAMI, GITA, FALLAH, FATEMEH, IRANI, SHIVA, & RAHBAR, MOHAMMAD. (2017). MOLECULAR DETECTION OF ISABA2 AMONG CARBAPENEM HYDROLYZING CLASS D β-LACTAMASESE ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM PATIENTS IN TEHRAN HOSPITALS. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 11(3), 19-26. SID. https://sid.ir/paper/132652/en

    Vancouver: Copy

    OWRANG MINA, ESLAMI GITA, FALLAH FATEMEH, IRANI SHIVA, RAHBAR MOHAMMAD. MOLECULAR DETECTION OF ISABA2 AMONG CARBAPENEM HYDROLYZING CLASS D β-LACTAMASESE ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM PATIENTS IN TEHRAN HOSPITALS. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2017;11(3):19-26. Available from: https://sid.ir/paper/132652/en

    IEEE: Copy

    MINA OWRANG, GITA ESLAMI, FATEMEH FALLAH, SHIVA IRANI, and MOHAMMAD RAHBAR, “MOLECULAR DETECTION OF ISABA2 AMONG CARBAPENEM HYDROLYZING CLASS D β-LACTAMASESE ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM PATIENTS IN TEHRAN HOSPITALS,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 11, no. 3, pp. 19–26, 2017, [Online]. Available: https://sid.ir/paper/132652/en

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